| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:A110
CAS:1185388-35-5
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
|
Quinoline, 4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]-, 1-oxide manufacturers
- A110
-
- $1980.00 / 50mg
-
2024-10-24
- CAS:1185388-35-5
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | Quinoline, 4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]-, 1-oxide Basic information |
| | Quinoline, 4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]-, 1-oxide Chemical Properties |
| Melting point | 172-174 °C | | Boiling point | 588.0±60.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | pka | 2.32±0.10(Predicted) |
| | Quinoline, 4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]-, 1-oxide Usage And Synthesis |
| Description | A110 is a potent and selective inhibitor of IMPDHs. A110 binds to the NAD(+) cofactor site and forms a ternary complex with IMP. | | Uses | A110 is the inhibitor for Cryptosporidium parvum inosine monophosphate dehydrogenase (CpIMPDH). A110 inhibits CpIMPDH in Toxoplasma gondii with IC50 of 18 nM. A110 exhibits pro-parasitic efficacy and cause parasitemia[1]. | | References | [1] Gorla SK, et al., Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrob Agents Chemother. 2014;58(3):1603-14. DOI:10.1128/AAC.02075-13 |
| | Quinoline, 4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]-, 1-oxide Preparation Products And Raw materials |
|