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Postion:Product Catalog >Pharmaceutical intermediates>Heterocyclic compound>Pyrimidines>Methylpyrimidine> 6-Methyluracil
6-Methyluracil
  • 6-Methyluracil
  • 6-Methyluracil

6-Methyluracil NEW

Price $6 $5 $1
Package 1KG 25KG 100KG
Min. Order: 1KG
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-03-29

Product Details

Product Name: 6-Methyluracil CAS No.: 626-48-2
Min. Order: 1KG Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/03/29
Lead time: In stock Packaging: bottle/drum/bucket/IBC, as request.
Delivery: By sea, by air, by express Origin: Manufacturer
Name: Sun

1. Product information

Names

Name6-methyluracil
SynonymMore Synonyms

 6-Methyluracil Biological Activity

Description6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo[1][2].
Related Catalog
Research Areas >> Metabolic Disease
In Vivo6-Methyluracil (50 mg/kg; a single i.p.) produces a pronounced radioprotective effect in BALB and SHK mice[2].
References

[1]. Cromby CH, et, al. 6-Methyluracil excretion in 2-methylacetoacetyl-CoA thiolase deficiency and in two children with an unexplained recurrent ketoacidaemia. J Inherit Metab Dis. 1994;17(1):81-4.

[2]. Taran IP, et, al. [The antiradiation action of 6-methyluracil]. Radiobiologiia. Mar-Apr 1993;33(2):285-90.

 Chemical & Physical Properties

Density1.2±0.1 g/cm3
Melting Point318 °C (dec.)(lit.)
Molecular FormulaC5H6N2O2
Molecular Weight126.113
Flash Point208ºC
Exact Mass126.042931
PSA65.72000
LogP-0.12
Index of Refraction1.490
Water Solubility7 g/L (22 ºC)

 MSDS

6-Methyluracil MSDS(Chinese)

 Toxicological Information

CHEMICAL IDENTIFICATION

  • RTECS NUMBER :

  • YR0700000

  • CHEMICAL NAME :

  • Uracil, 6-methyl-

  • CAS REGISTRY NUMBER :

  • 626-48-2

  • LAST UPDATED :

  • 199701

  • DATA ITEMS CITED :

  • 9

  • MOLECULAR FORMULA :

  • C5-H6-N2-O2

  • MOLECULAR WEIGHT :

  • 126.13

  • WISWESSER LINE NOTATION :

  • T6MVMVJ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 64500 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 03FEB1981

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • >7500 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 44,56,1955

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Intraperitoneal

  • SPECIES OBSERVED :

  • Rodent - mouse

  • DOSE/DURATION :

  • 2700 mg/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 27,112,1993

  • TYPE OF TEST :

  • LD50 - Lethal dose, 50 percent kill

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Mammal - species unspecified

  • DOSE/DURATION :

  • 2 gm/kg

  • TOXIC EFFECTS :

  • Details of toxic effects not reported other than lethal dose value

  • REFERENCE :

  • RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 48,186,1985 ** TUMORIGENIC DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • SPECIES OBSERVED :

  • Rodent - rat

  • DOSE/DURATION :

  • 18 gm/kg/52W-C

  • TOXIC EFFECTS :

  • Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors

  • REFERENCE :

  • VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 8(10),49,1962 ** REPRODUCTIVE DATA **

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Oral

  • DOSE :

  • 2 gm/kg

  • SEX/DURATION :

  • female 10 day(s) after conception

  • TOXIC EFFECTS :

  • Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - urogenital system

  • REFERENCE :

  • BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 66,1382,1968

  • TYPE OF TEST :

  • TDLo - Lowest published toxic dose

  • ROUTE OF EXPOSURE :

  • Subcutaneous

  • DOSE :

  • 20 mg/kg

  • SEX/DURATION :

  • female 4 day(s) pre-mating

  • TOXIC EFFECTS :

  • Reproductive - Maternal Effects - uterus, cervix, vagina

  • REFERENCE :

  • JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6. Volume(issue)/page/year: 19,264,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1624 No. of Facilities: 89 (estimated) No. of Industries: 5 No. of Occupations: 6 No. of Employees: 293 (estimated) No. of Female Employees: 109 (estimated)

 Safety Information

SymbolArticle illustration
GHS08
Signal WordWarning
Hazard StatementsH361
Precautionary StatementsP281
Personal Protective Equipmentdust mask type N95 (US);Eyeshields;Gloves
Hazard CodesXn:Harmful
Risk PhrasesR62;R63
Safety PhrasesS36/37/39-S45-S36/37
RIDADR1759
WGK Germany3
RTECSYR0700000
Packaging GroupII
Hazard Class8
HS Code2942000000

 Synthetic Route

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Literature: Novakov; Orlinson; Navrotskii Russian Journal of Organic Chemistry, 2005 , vol. 41, # 4 p. 607 - 609
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6-Methyluracil

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Literature: Font, David; Linden, Anthony; Heras, Montserrat; Villalgordo, Jose M. Tetrahedron, 2006 , vol. 62, # 7 p. 1433 - 1443
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~77%

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6-Methyluracil

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Literature: Botta; Summa; Saladino; Nicoletti Synthetic Communications, 1991 , vol. 21, # 21 p. 2181 - 2187

 Precursor & DownStream

Precursor  9

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DownStream  8

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 Customs

HS Code2933599090
Summary2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles26

More Articles
An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial

Reprod. Toxicol. 28(4) , 503-10, (2009)

The chick micromass culture system has advantages over the validated rat system – ready availability and non-culling of the donor parent – but needs to give comparable results. This study confirmed co...

Arginine glutamate improves healing of radiation-induced skin ulcers in guinea pigs.

Int. J. Radiat. Biol. 89(12) , 1108-15, (2013)

The increase in the incidence of the radiation-induced skin injury cases and the absence of standard treatments escalate the interest in finding new and effective drugs for these lesions. We studied t...

Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.

Bioorg. Med. Chem. Lett. 14(9) , 2269-74, (2004)

The synthesis of a series of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils is discussed. SAR around N-1 of the uracil was explored, which led to the discovery that an electro...

 Synonyms

6-Methyluracil
2,4-Dihydroxy-6-methylpyrimidine
2,4(1H,3H)-Pyrimidinedione, 6-methyl-
6-Methylpyrimidin-2,4(1H,3H)-dion
EINECS 210-949-4
6-Methyl-2,4(1H,3H)-pyrimidinedione
6-Methylpyrimidine-2,4(1H,3H)-dione
6-methyl-1H-pyrimidine-2,4-dione
6-methylpyrimidine-2,4-diol
MFCD00006028




2. Packaging

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                     Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address : Sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 86 13526505137





Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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Henan Fengda Chemical Co., Ltd

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  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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