Resorcinol diglycidyl ether NEW

• DATA ITEMS CITED :

• 34

• MOLECULAR FORMULA :

• C12-H14-O4

• MOLECULAR WEIGHT :

• 222.26

• WISWESSER LINE NOTATION :

• T3OTJ B1OR CO1- BT3OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• Standard Draize test

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - rabbit

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 2570 mg/kg

• TOXIC EFFECTS :

• Gastrointestinal - ulceration or bleeding from duodenum

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 178 mg/kg

• TOXIC EFFECTS :

• Behavioral - somnolence (general depressed activity) Gastrointestinal - peritonitis

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 980 mg/kg

• TOXIC EFFECTS :

• Behavioral - somnolence (general depressed activity)

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 243 mg/kg

• TOXIC EFFECTS :

• Behavioral - somnolence (general depressed activity) Gastrointestinal - peritonitis

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 1240 mg/kg

• TOXIC EFFECTS :

• Behavioral - somnolence (general depressed activity)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 5320 mg/kg/14D-I

• TOXIC EFFECTS :

• Related to Chronic Data - death

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 13 gm/kg/13W-I

• TOXIC EFFECTS :

• Related to Chronic Data - death

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 10500 mg/kg/14D-I

• TOXIC EFFECTS :

• Related to Chronic Data - death

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 26 gm/kg/13W-I

• TOXIC EFFECTS :

• Related to Chronic Data - death

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 6180 mg/kg/2Y-I

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 25750 mg/kg/2Y-I

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Unreported

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 6700 mg/kg

• TOXIC EFFECTS :

• Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 51500 mg/kg/2Y-I

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 25750 mg/kg/2Y-I

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 12875 mg/kg/2Y-I

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

• TYPE OF TEST :

• Sex chromosome loss and nondisjunction

• TYPE OF TEST :

• Heritable translocation test

MUTATION DATA

• TYPE OF TEST :

• Sister chromatid exchange

• TEST SYSTEM :

• Rodent - hamster Ovary

• DOSE/DURATION :

• 50 ug/L

• REFERENCE :

• SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,181,1985 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,181,1985 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83725 No. of Facilities: 193 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 2994 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83725 No. of Facilities: 28 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 1856 (estimated) No. of Female Employees: 222 (estimated)