Tannic acid NEW
| Price | $8 | $5 | $1 |
| Package | 1kg | 25kg | 100kg |
| Min. Order: | 1kg |
| Supply Ability: | g-kg-tons, free sample is available |
| Update Time: | 2024-04-05 |
Product Details
| Product Name: Tannic acid | CAS No.: 1401-55-4 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: g-kg-tons, free sample is available | Release date: 2024/04/05 |
| Lead time: In stock | Packaging: bottle/drum/bucket/IBC, as request. |
| Delivery: By sea, by air, by express | Origin: Manufacturer |
| NAME: Sun |
1. Product information
| Name | tannic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. |
|---|---|
| Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Natural Products >> Phenols Research Areas >> Cancer Research Areas >> Inflammation/Immunology |
| Target | IC50: 3.4 μM (hERG channel)[1] |
| In Vivo | During the course of treatment, tannic acid significantly ameliorates these phenotypes in AD skin lesions. Tannic acid treatment aslo reduces these dermal changes compare with AD mice. Treatment with tannic acid increases PPARγ expression in AD skin sections. The PPARγ protein expression is suppressed in vehicle-treated AD mice, but when treats with tannic acid, its expression is increased dramatically. The IL-1β, TNFα, TNFR1, and COX2 protein expressions are significantly up-regulated in vehicle-treated AD mice, but significantly suppressed by tannic acid treatment[2]. |
| Animal Admin | Specific pathogen-free female 6 weeks old mice are used. The animals are maintained in a controlled room (temperature 23±2 °C, humidity 55±15%, 12 h light cycle). After 1 week, the mice arer andomly divided into 3 groups, untreated group-receive vehicle (distill water) (Normal, n=5); DfE cream treated mice (100 mg/mouse) is divided into two groups and each receives vehicle (distill water) (AD, n=5) or Tannic acid (80 mg/kg/day, per oral) (AD+Tannic acid, n=5) and are allowed free access to drinking water and standard laboratory diet[2]. |
| References | [1]. Xi Chu, et al. Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. PLoS One. 2015; 10(12): e0143797. [2]. Karuppagounder V, et al. Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression. Cytokine. 2015 Dec;76(2):206-13. |
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Melting Point | 218 °C(lit.) |
| Molecular Formula | C76H52O46 |
| Molecular Weight | 1701.198 |
| Flash Point | 198°C |
| Exact Mass | 1700.172974 |
| PSA | 777.98000 |
| LogP | 13.33 |
| Index of Refraction | 1.927 |
| Stability | Stable. Incompatible with metallic salts, strong oxidizing agents, iron and other heavy metals. |
| Water Solubility | 250 g/L (20 ºC) |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
For more details, pls contact us freely.
Email address : sun@fdachem.com
Mob: 86 13526505137
WhatsApp/Skype/Wechat/LINE: 86 13526505137
Company Profile Introduction
Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.
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China
- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
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