Product Details
| Product Name:
1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid |
CAS No.:
1193383-09-3 |
| Min. Order:
1KG |
Purity:
95%~99.99% |
| Supply Ability:
10 MT/ Month |
Release date:
2024/10/22 |
Heidi 115
| 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid Basic information |
| Product Name: |
1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid |
| Synonyms: |
1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid;JNJ-42041935;1-[6-Chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-1H-pyrazole-4-carboxylic acid;HIF-PHD Inhibitor II;CS-1577;JNJ 42041935;JNJ42041935;HIF-PHD INHIBITOR II;1-(5-Chloro-6-(trifluoromethoxy)-1H-benzo[d]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid |
| CAS: |
1193383-09-3 |
| MF: |
C12H6ClF3N4O3 |
| MW: |
346.6492496 |
| EINECS: |
|
| Product Categories: |
|
| Mol File: |
1193383-09-3.mol |
 |
| |
| 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid Chemical Properties |
| Boiling point |
555.9±60.0 °C(Predicted) |
| density |
1.82±0.1 g/cm3(Predicted) |
| pka |
3.52±0.10(Predicted) |
| |
| 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid Usage And Synthesis |
| Uses |
Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzymes act as central gatekeepers of posttranscriptional and transcriptional adaptation to hypoxia, oxidative stress, and excitotoxicity. Their catalytic activity is dependent on iron, 2-oxoglutarate (2-OG), and oxygen, and leads to the stabilization of a host of proteins, including the hypoxia-inducible transcription factors in response to oxygen availability. Inhibitors of PHD have been used to mimic a hypoxic response in order to study a range of oxygen-deprivation-related disorders, including anemia, ulcerative colitis, myocardial ischemia, stroke, and metabolic disorders. JNJ-42041935 is a selective, 2-OG competitive, and reversible inhibitor of PHD enzymes (pKis = 7.91, 7.29, and 7.65 for PHD1, 2, and 3, respectively). It is >100-fold selective for PHD compared to the related FIH (factor-inhibiting HIF) and a panel of various other enzymes. In an inflammation-induced anemia model in rats, 100 μM/kg/day JNJ-42041935 significantly increased the number of circulating reticulocytes and red blood cells, increased blood hemoglobin and hematocrit, and restored mean corpuscular volume and mean cell hemoglobin of red bloods cells.[Cayman Chemical] |
Company Profile Introduction
Technology research and transfer of pilot screening, pilot scale-up and mass production solutions , for pharmaceutical intermediates, biologicals and fine chemicals (Not including inflammable , explosive , hazardous goods ) ; Market : Nano material , metal catalyst , raw material of cosmetics , pharmaceutical intermediates , chemicals , photoelectric material , import and export of technology and goods (For projects subject to approval according to law, business activities can be carried out only after approval by relevant departments ).
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$34.00/1mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-11-10 |
|
|
$0.00/1G |
VIP2Y
|
Hubei Lidu New Material Technology Co., Ltd
|
2025-11-04 |
|
|
$10.00/1ASSAYS |
VIP5Y
|
RongNa Biotechnology Co.,Ltd
|
2025-08-21 |
|
|
$0.00/1kg |
VIP2Y
|
HANGZHOU HAILAN CHEMICAL CO.,LTD.
|
2025-08-21 |
China