12-HETE NEW
| Price | $925 |
| Package | 100μg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: 12-HETE | CAS No.: 71030-37-0 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | 12-HETE |
| Description | 12-HETE ((±)12-HETE) is a modulator of PGE2, with both anti-thrombotic and pro-thrombotic effects, inducing PGE2 release and COX-2 expression via phospholipase A2 (sPLA2-IIA) inducers. It is also a neuroregulator activating retinal cell endothelial dysfunction in diabetic retinopathy. |
| In vitro | 12-HETE (0.1 μM) activates Muller cells (MCs), enhances glutamate production, and induces inflammation and oxidation. [1] 1 μM exogenous 12-HETE significantly reduced SD-induced cell viability. 12-HETE inhibited SD-induced caspase-3 activity in a concentration-dependent manner with IC50 of 1.13 μM. In OVCAR-3 cells, treatment with 1 μM 12-HETE resulted in increased ILK expression. 1 μM 12-HETE induced the expression of Bcl-2, an anti-apoptotic protein, and inhibited the expression of Bax, a pro-apoptotic protein, and these effects were attenuated by ILK siRNA. [2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : Miscible DMSO : Miscible PBS (pH 7.2) : 0.8 mg/mL (2.5 mM), Sonication is recommended. 0.1 M Na2CO3 : 2 mg/mL (6.24 mM), Sonication is recommended. DMF : Miscible |
| Keywords | 12-HETE | 12HETE | 12 HETE |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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