L-Lysine NEW

L-Lysine Cas 56-87-1

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L-Lysine is an essential amino acid, meaning the human body cannot synthesize it and must obtain it through diet or supplementation. It plays critical roles in protein synthesis, hormone production, enzyme function, and immune support.

🔬 Basic Facts About L-Lysine

Chemical name: (2S)-2,6-diaminohexanoic acid

One-letter code: K

Three-letter code: Lys

Essential?: Yes — must be obtained from food or supplements

Rich dietary sources:

Animal proteins: red meat, poultry, fish, eggs, dairy (especially cheese)

Plant sources: legumes (e.g., lentils, chickpeas), quinoa, pistachios, pumpkin seeds

(Note: Most grains are low in lysine, which is why plant-based diets require careful planning)

💡 Key Biological Functions

Protein synthesis: Building block for all human proteins.

Carnitine production: Lysine is a precursor to carnitine, which helps transport fatty acids into mitochondria for energy production.

Calcium absorption: Supports intestinal calcium uptake and bone health.

Collagen cross-linking: Works with vitamin C to stabilize collagen — essential for skin, tendons, and connective tissue.

Immune modulation: May influence antibody production and antiviral defense.

💊 Common Uses & Applications

1. Herpes Simplex Virus (HSV) Management

Most well-known use: Prevention and treatment of cold sores (oral herpes) and genital herpes.

Proposed mechanism: Lysine may antagonize arginine, an amino acid that HSV needs to replicate. High lysine / low arginine environments may suppress viral reactivation.

Evidence: Mixed clinical results. Some studies show reduced outbreak frequency/duration; others show no benefit. Still widely used as a supplement for this purpose.

Typical dose: 500–1,000 mg daily for prevention; up to 3,000 mg/day during outbreaks.

2. Bone Health & Osteoporosis Support

Enhances calcium retention and may reduce urinary calcium loss.

Potential role in supporting bone density, especially when combined with calcium and vitamin D.

3. Anxiety & Stress Reduction

Some research suggests lysine (often with L-arginine) may help lower stress-induced anxiety by modulating serotonin receptors and cortisol levels.

Studied in populations with chronic stress or marginal lysine intake.

4. Wound Healing & Tissue Repair

Supports collagen formation and protein synthesis needed for recovery after injury, surgery, or burns.

5. Animal Feed Additive

Widely added to livestock and poultry feed (especially corn-based diets, which are lysine-deficient) to improve growth and feed efficiency.

6. Vegan/Vegetarian Nutrition

Used as a supplement to correct potential lysine deficiency in plant-based diets lacking legumes or fortified foods.

⚠️ Safety & Considerations

Generally safe at typical doses (up to 3 g/day).

High doses (>10 g/day long-term) may cause:

Gastrointestinal upset (nausea, diarrhea)

Kidney strain (caution in people with renal disease)

Theoretical risk of increased gallstone formation

Drug interactions: May interact with aminoglycoside antibiotics (increased kidney toxicity risk).

📌 Summary

L-Lysine is an essential amino acid vital for protein building, immune function, collagen formation, and carnitine synthesis. Its most popular use is in managing herpes simplex outbreaks, though evidence is mixed. It also supports bone health, stress response, and tissue repair, and is crucial in balanced nutrition—especially for vegetarians/vegans.

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