2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid NEW
| Price | $522 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-29 |
Product Details
| Product Name: 2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid | CAS No.: 24967-27-9 |
| Supply Ability: 10g | Release date: 2025/08/29 |
Product Introduction
Bioactivity
| Name | 2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid |
| Description | 2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid is a pan-sialidase (neuraminidase, NEU) inhibitor with inhibitory activity against sialidases 1–4, with an IC50 of 43–143 μM, and also exhibits inhibitory activity against various influenza viruses. |
| In vitro | Methods: To evaluate the effect on sialidase activity in pancreatic β-cells, INS-1D cells were used, and in vitro enzymatic activity was measured using the substrate 4MU-Neu5Ac (2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid). Results: N-acetyl-2,3-dehydro-2-deoxyneuraminic acid (DANA / Neu5Ac2en) significantly inhibited sialidase activity in INS-1D cells at concentrations ranging from 10 to 100 μM in a dose-dependent manner [1]. |
| In vivo | Methods: A mouse model of pulmonary fibrosis was established using bleomycin. Starting on day 10 after bleomycin administration, mice were intraperitoneally injected with 2,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid (DANA) at a dose of 10 mg/kg daily. Treatment continued until day 21, at which point the animals were euthanized for tissue analysis. Results: Inhibition of sialidase activity starting on day 10 after bleomycin administration significantly attenuated pulmonary fibrosis, suggesting that DANA exerts anti-fibrotic effects.[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF : < 1 mg/ml (insoluble), Sonication is recommended. DMSO : 1 mg/mL (3.43 mM), Sonication is recommended. PBS (pH 7.2) : 10 mg/mL (34.33 mM), Sonication is recommended. |
| Keywords | 2,3-Dehydro-2-deoxy-N-acetylneuraminic acid | 2,3Dehydro2deoxyNacetylneuraminic acid | 2,3 Dehydro 2 deoxy N acetylneuraminic acid |
| Inhibitors Related | Acetylcysteine | α-Vitamin E | Molnupiravir | AEBSF hydrochloride | Umifenovir hydrochloride | Nitazoxanide | Camphor | Curcumin | Naringenin | Salcomine | Coumarin | Crystal Violet |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1kg |
VIP1Y
|
Xi an Biohorlden Industry Trade Co Ltd
|
2025-04-11 | |
| $990.00/5g |
VIP2Y
|
R&D Scientific Inc.
|
2025-11-24 | |
| $/ |
VIP5Y
|
RongNa Biotechnology Co.,Ltd
|
2025-04-29 | |
| $1.00/1KG |
VIP6Y
|
Career Henan Chemical Co
|
2019-12-20 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY