3-Bromo-7-nitroindazole NEW
| Price | $46 | $76 | $189 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-05 |
Product Details
| Product Name: 3-Bromo-7-nitroindazole | CAS No.: 74209-34-0 |
| Purity: 97.44% | Supply Ability: 10g |
| Release date: 2025/12/05 |
Product Introduction
Bioactivity
| Name | 3-Bromo-7-nitroindazole |
| Description | 3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor that affects the synthesis of the intercellular messenger NO throughout the brain and body. |
| In vivo | Male rats received either 3-Bromo-7-nitroindazole (20mg/kg/day) or saline via intraperitoneal injection for 5days. Daily administration of the specific neuronal nitric oxide synthase (nNOS) inhibitor, 3-Bromo-7-nitroindazole impaired the acquisition of the Morris water maze (MWM) paradigm task. 3-Bromo-7-nitroindazole also impaired the probe trial. The MWM training was associated with a significant increase in the brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. BDNF mRNA expression in the hippocampus did not change after 3-Bromo-7-nitroindazole treatment. L-arginine significantly reversed behavioural parameters, and the effect of 3-Bromo-7-nitroindazole was found to be NO-dependent. There were no differences in locomotor activity and blood pressure in 3-Bromo-7-nitroindazole treated rats[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (16.53 mM), Sonication is recommended. DMSO : 100 mg/mL (413.17 mM), Sonication is recommended. |
| Keywords | NOS | NO Synthase | nNOS | Nitric oxide synthases | Inhibitor | inhibit | 3-Bromo-7-nitroindazole | 3Bromo7nitroindazole | 3 Bromo 7 nitroindazole |
| Inhibitors Related | 2-Isopropyl-1H-imidazole | Chondroitin sulfate | L-NAME hydrochloride | Mifepristone | Aminopicoline | 3-AMINO-1,2,4-TRIAZINE | L-Arginine | Ethyl cinnamate | Methylene Blue trihydrate | Gluconate Calcium | Diallyl disulfide | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | Neuroprotective Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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