Product Details
| Product Name: 3-?Isoquinolinecarboxyl?ic acid, 4-?hydroxy-?1-?methyl-?7-?phenoxy-?, ethyl ester | CAS No.: 1421312-34-6 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: 200kg | Release date: 2025/07/08 |
3-Isoquinolinecarboxylic acid, 1-chloro-4-hydroxy-7-phenoxy-, methyl ester
It is a white to off-white crystalline solid with a molecular weight of 285.69 g/mol and a melting point of 136-138 °C.
It is soluble in organic solvents such as methanol, ethanol, acetone and dichloromethane.
It is an intermediate for the synthesis of roxadustat, a drug for the treatment of anemia associated with chronic kidney disease.
Roxadustat is an oral inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH), which stimulates erythropoiesis by increasing the production of erythropoietin and iron absorption.
Roxadustat is marketed in China and Japan and is under development in other countries.
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