Sodium hyaluronate

Sodium sulphate (SODIUM HYALURONATE) is a substance extracted from cockscomb. It can also be obtained by fermentation of lactic acid bacteria. It is white or off-white granules or powder, and has no odor. When dried, the nitrogen content is 2.8%-4.0%. The glucuronic acid content is from 37.0% to 51.0%. More use in the cosmetics field, moisturizing effect

Basic Information

Chinese name: sodium hyaluronate (from the cockscomb)
English name: Sodium Hyaluronate from Cockscomb
English alias: Hyaluronic Acid Sodium Salt
CAS No.: 9067-32-7
MDL number: MFCD00875848

1. It is a biochemical drug with high clinical value and is widely used in various ophthalmic operations such as crystal implantation, corneal transplantation and anti-glaucoma surgery. It can also be used to treat arthritis and accelerate wound healing. It can be used in cosmetics to protect the skin. It can keep the skin moist and smooth, delicate and tender, elastic, anti-wrinkle, anti-wrinkle, beauty care and restore skin physiological function.
2. Use It can be used in cosmetics such as cream, cream, honey, milk, mask, shampoo, etc. to maintain the moisture of skin and hair, moisturize the skin, hair, increase luster, and prevent skin cracking and wrinkles.
Reference formula and preparation process of hyaluronic acid skin cream: taking 7 7 g of stearic acid, 10.5 g of liquid paraffin, 3 5 g of white petrolatum, 3 5 g of glyceryl monostearate, and heating to 80 ° C, Another 2 3 5 g of water was added, sodium dodecyl sulfate 0.7 g and triethanolamine 2.5 g, heated to 80 ° C, then added 10% paraben liquid 3. 5 mL and glycerol 1 4 g, slowly pour the oil phase into the water phase, while stirring in the same direction, when the temperature drops to about 70 °C, pour 0.25% hyaluronic acid solution into the above liquid. Add a little flavor and mix quickly to a semi-solid shape.
3. Treat arthritis and accelerate wound healing.

nature

Commercial hyaluronic acid is in the form of its sodium salt, sodium hyaluronate (SH).
It is a white fibrous or powdery solid, has strong hygroscopicity, is soluble in water, and is insoluble in organic solvents such as alcohol, ketone and ether. Its aqueous solution is negatively charged and has high viscoelasticity and osmotic pressure at high concentrations. HA is easily decomposed by acid, alkali or heat treatment; in the presence of metal ions such as iron and copper and a reducing agent such as ascorbic acid or cysteine, it is degraded by oxygen free radicals, xenon rays, gamma rays, ultraviolet rays and ultrasonic waves. It can also be broken down by hyaluronidase and chondroitinase. High molecular weight HA can be low molecular weight under the conditions of enzyme, acid, heating, etc. In addition, HA aqueous solution is a non-Newtonian fluid with good viscoelasticity and flow deformation. Based on the special properties of HA, HA can be widely used in medicine, cosmetics and health foods. HA is mainly used in clinical treatment, diagnosis, cosmetic matrix and nutraceuticals. Commercial HA is generally in the form of its sodium salt, and other metal salts such as zinc salts are rarely used. The quality standards for medicinal HA are higher, and the HA for cosmetics and health foods is second.