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Postion:Product Catalog >Natural Products>Alkaloids>CYTOCHALASIN D

CYTOCHALASIN D

$1.00 / 1kg

  • 1kg
Min. Order: 1g
Purity: 99%
Cas No.: 22144-77-0
Supply Ability: 100KG
Overview
  • Product Name: CYTOCHALASIN D
  • CAS No.: 22144-77-0
  • Min. Order:1g
  • Purity:99%
  • Supply Ability:100KG
  • Release date:2019/07/06
  • Product::AD68
Product Advantage
CYTOCHALASIN D Basic information
Product Name: CYTOCHALASIN D
Synonyms: ZYGOSPORIN A;CYTOCHALASIN D;CYTOCHALASIN D, ZYGOSPORIUM MANSONII;CYTOCHALASIN D, ZYGUSPORIUM MANSONII;(7S,13E,16S,18R,19E,21R)-21-(ACETYLOXY)-7,18-DIHYDROXY-16,18-DIMETHYL-10-PHENYL[11]CYTOCHALASA-6(12),13,19-TRIENE-1,17-DIONE;(11)cytochalasa-6(12),13,19-triene-1,17-dione,21-(acetyloxy)-7,18-dihydroxy-16;,12,15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-,15-acetate;,18-dimethyl-10-phenyl-,(7s,13e,16s,18r,19e,21r)-
CAS: 22144-77-0
MF: C30H37NO6
MW: 507.62
EINECS: 244-804-1
Product Categories: Caspases/Apoptosis;antibiotic
Mol File: 22144-77-0.mol
CYTOCHALASIN D Structure
 
CYTOCHALASIN D Chemical Properties
Melting point  255-260°C
Boiling point  595.84°C (rough estimate)
density  1.1764 (rough estimate)
refractive index  1.6310 (estimate)
Fp  87℃
storage temp.  −20°C
solubility  DMSO: soluble
 
Safety Information
Hazard Codes  T
Risk Statements  25-63
Safety Statements  36/37-45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  GZ4850000
HazardClass  6.1(a)
PackingGroup  I
MSDS Information
Provider Language
SigmaAldrich English
 
CYTOCHALASIN D Usage And Synthesis
Chemical Properties Powder
Uses Cytochalasin D acts as an anti-hypertensive drug acting on human intestinal epithelial caco-2 cells. Also has activity in HMG-CoA reductase inhibitors used in the lowering of cholesterol. Actin inhib itor, actin polymerization inhibitor affecting cell movement, growth, phagocytosis and even secretion.
Uses Cytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumour agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.
Uses Cytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumor agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.
Uses A cell cycle arresting compound used in actin polymerization studies and cytological research
Definition ChEBI: An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.
General Description Needles or fluffy white powder.
Reactivity Profile CYTOCHALASIN D may be sensitive to exposure to heat. CYTOCHALASIN D can react with strong oxidizing agents, strong acids and strong bases. .
Fire Hazard Flash point data for CYTOCHALASIN D are not available; however, CYTOCHALASIN D is probably combustible.
Biological Activity Potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B, does not inhibit monosaccharide transport across the plasma membrane.
Safety Profile Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
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