5Z-7-Oxozeaenol NEW
| Price | $326 | $733 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-09 |
Product Details
| Product Name: 5Z-7-Oxozeaenol | CAS No.: 253863-19-3 |
| Purity: 99.00% | Supply Ability: 10g |
| Release date: 2025/12/09 |
Product Introduction
Bioactivity
| Name | 5Z-7-Oxozeaenol |
| Description | 5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM. |
| In vitro | 5Z-7-Oxozeaenol is a natural anti-protozoan compound from the fungal origin with inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC with IC50s of 110, 170, 340, 6300, and 6600 nM, respectively[1]. 5Z-7-Oxozaeenol inhibited PMA-induced AP-1 activity to almost basal levels in KT cells but had no effect on IL-1-induced NF-kB activity in KK cells[2]. 5Z-7-Oxozaeenol inhibits the JNK/p38 pathway, but it is not a direct inhibitor and is signal-specific. 5Z-7-Oxozaeenol prevents inflammation by inhibiting the catalytic activity of the TAK1 MAPK kinase[3]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (110.38 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2 mg/mL (5.52 mM), Sonication is recommeded. |
| Keywords | VEGFR-3 | VEGFR3 | VEGFR-2 | VEGFR2 | VEGFR | Vascular endothelial growth factor receptor | TAK1 | SRC | Src | PDGFR-β | PDGFRβ | MEK1 | MAP3K | MAP kinase kinase kinase, MEKK, MAPKKK | L-783279 | L 783279 | Inhibitor | inhibit | FR-148083 | FR 148083 | FLT3 | B-RAF VE | B-Raf (VE) | Antibiotic | 5Z-7-Oxozeaenol | 5Z7Oxozeaenol | 5Z 7 Oxozeaenol |
| Inhibitors Related | Neomycin sulfate | Ampicillin sodium | Doxycycline (hyclate) | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Doxycycline | Penicillin G potassium | EDTA copper(II) disodium salt | Ethyl acetoacetate | Ampicillin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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