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Postion:Product Catalog >Pharmaceutical intermediates>Heterocyclic compound>Pyridine compound>Aminopyridine>4-Dimethylaminopyridine 1122-58-3 In stock N,N-Dimethylpyridin-4-amine DMAP
4-Dimethylaminopyridine 1122-58-3   In stock   N,N-Dimethylpyridin-4-amine  DMAP
  • 4-Dimethylaminopyridine 1122-58-3   In stock   N,N-Dimethylpyridin-4-amine  DMAP

4-Dimethylaminopyridine 1122-58-3 In stock N,N-Dimethylpyridin-4-amine DMAP

Price $1.5 $1.1
Package 1KG 25KG
Min. Order: 1KG
Supply Ability: bulk metric tons per month
Update Time: 2020-06-02

Product Details

Product Name: 4-Dimethylaminopyridine 1122-58-3 In stock N,N-Dimethylpyridin-4-amine DMAP CAS No.: 1122-58-3
Min. Order: 1KG Purity: 99.5% high quality purified in stock
Supply Ability: bulk metric tons per month Release date: 2020/06/02
E-mail: chemwill_asia@126.com;chemwill@hotmail.com Contact person: Ms Ella Su Manager


Product no. chemwill4DPE1002


4-Dimethylaminopyridine 1122-58-3   In stock   N,N-Dimethylpyridin-4-amine  DMAP


Product Name:    4-Dimethylaminopyridine
Synonyms:    Valacyclovir EP Impurity G;4-(dimethylamino)-pyridin;4-Dimethylaminepyridine;gamma-(Dimethylamino)pyridine;N,N-Dimethyl-4-aminopyridine;n,n-dimethyl-4-pyridinamin;p-Dimethylaminopyridine;Pyridine, 4-(dimethylamino)-
CAS:    1122-58-3
MF:    C7H10N2
MW:    122.17
EINECS:    214-353-5
Product Categories:    Fluorescent Labels & Indicators;Nucleotides;-;Amines;Aromatics;Pyridine;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines derivates;Other Reagents;Biochemistry;Condensation & Active Esterification;Reagents for Oligosaccharide Synthesis;Synthetic Organic Chemistry;Materials Science;Bases & Related Reagents
Mol File:    1122-58-3.mol
4-Dimethylaminopyridine Structure
4-Dimethylaminopyridine Chemical Properties
Melting point     83-86 °C(lit.)
Boiling point     211 °C
density     0.906 g/mL at 25 °C
refractive index     n20/D 1.431
Fp     110 °C
storage temp.     Store in dark!
solubility     methanol: 50 mg/mL, clear
form     prilled
pka    pKa (20°): 9.7
color     off-white to yellow
PH    11 (60g/l, H2O, 20℃)
Water Solubility     76 g/L (25 ºC)
Merck     14,3389
BRN     110354
Stability:    Stable. Incompatible with acids, oxidizing agents.
CAS DataBase Reference    1122-58-3(CAS DataBase Reference)
NIST Chemistry Reference    4-Pyridinamine, N,N-dimethyl-(1122-58-3)
EPA Substance Registry System    4-Pyridinamine, N,N-dimethyl-(1122-58-3)
Safety Information
Hazard Codes     T,C,T+,Xn,F
Risk Statements     25-34-24/25-36/37/38-27-36-24-20-61-40-23/24/25-67-66-21/22-11-36/37-22-19
Safety Statements     36/37/39-45-28A-26-28-36/37-53-27-22-16
RIDADR     UN 2811 6.1/PG 2
WGK Germany     3
RTECS     US8400000
Autoignition Temperature    420 °C
Hazard Note     Toxic/Corrosive
TSCA     T
HazardClass     8
PackingGroup     II
HS Code     29333999


Name         4-Dimethylaminopyridine
Synonyms         N,N-Dimethylpyridin-4-amine; DMAP
copyRight
Molecular Structure         CAS # 1122-58-3, 4-Dimethylaminopyridine, N,N-Dimethylpyridin-4-amine, DMAP
Molecular Formula         C7H10N2
Molecular Weight         122.17
CAS Registry Number         1122-58-3
EINECS         214-353-5
 
Properties
Melting point         108-113 ºC
Boiling point         162 ºC (50 mmHg)
Flash point         110 ºC
Water solubility         76 g/L (25 ºC)

 

 4-Dimethylaminopyridine (DMAP) is a derivative of pyridine with the chemical formula (CH3)2NC5H4N. This colourless solid is of interest because it is more basic than pyridine, owing to the resonance stabilisation from the NMe2 substituent.
Because of its basicity, DMAP is a useful nucleophilic catalyst for a variety of reactions such as esterifications with anhydrides, the Baylis-Hillman reaction, hydrosilylations, tritylation, the Steglich rearrangement, Staudinger synthesis of β-lactams and many more. Chiral DMAP analogues are used in kinetic resolution experiments of mainly secondary alcohols and Evans auxiliary type amides.
Basic Info
Chemical Name     4-Dimethylaminopyridine
Synonyms     

4-Dimethylaminopyrid; AURORA KA-6495; N-(4-Pyridyl)dimethylamine; 4-Pyridinamine, N,N-dimethyl-; 4-Dimethylaminepyridine; Expand
CAS No.     1122-58-3
Molecular Formula     C7H10N2
Molecular Weight     122.16800
PSA     16.13000
LogP     1.14760
Properties
Appearance & Physical State     white to yellow crystalline powder
Density     1.012 g/cm3
Boiling Point     162ºC (50 mmHg)
Melting Point     108-113ºC
Flash Point     110ºC
Refractive Index     n20/D 1.431
Water Solubility     76 g/L (25 ºC)
Stability     Stable. Incompatible with acids, oxidizing agents.
Storage Condition     Store in dark
Vapor Pressure     0.431mmHg at 25°C
Safety Info
RTECS     US8400000
Hazard Class     8
Safety Statements     S26-S28-S36/37/39-S45
HS Code     2933399090
WGK Germany     3
Packing Group     II
RIDADR     UN 1760/2811
Risk Statements     R24/25; R34
Hazard Codes     T
Symbol     GHS06, GHS08
Hazard Declaration     H302; H311; H315; H319; H335; H351
Caution Statement     P280; P301 + P312 + P330; P302 + P352 + P312; P304 + P340 + P312; P305 + P351 + P338; P337 + P313
Signal Word     Danger
Synthesis Route
Total 42 Documents

4-Dimethylaminopyridine Usage And Synthesis
Overview    4-Dimethylaminopyridine is highly powerful catalyst of organic synthesis. The treatment of substrates such as alcohols, phenols and amines with acetic anhydride (or acetyl chloride) in the presence of pyridine has provided a general acetylation method since the turn of the 20th century. However, this approach often proves to be unsatisfactory for the acetylation of deactivated substrates. It was not until the late 1960’s that certain 4-dialkylaminopyridines were found (independently by two research groups)[1, 2] to be much superior to pyridine as catalysts for difficult acetylations or acylations, in general.

Figure 1 the chemical structure of DMAP

4-Dialkylaminopyridines were soon found to have general applicability for catalysis of a wide variety of reactions. 4-dimethylaminopyridine’s (DMAP) wide applicability has been frequently reviewed since the first review appeared in 1978. [3] The accelerating pace of reported applications for DMAP and the availability of DMAP in commercial quantities, at modest prices, have continued to stimulate great interest in its use as a catalyst in the fields of organic, polymer, analytical and biochemistry. Today there are thousands of examples of the use of DMAP in far ranging fields of chemistry in both patents and the research literature. Many full-scale production processes utilizing DMAP have been and are being operated. Several pharmaceutical and agricultural products that rely on DMAP’s superior catalytic properties in their synthetic sequences have been produced for years. Since 1976 more than 11,000 US patents have been granted which mention DMAP or dimethylaminopyridine.
The functional groups and class of compounds that are involved in the reactions with DMAP include alcohols, amines, arenes, azides, carbenes, enols, epoxides, hydrazines, hydroxylamines, phenols, thiols, lipids, sugars, aminoacids, peptides, alkaloids, steroids, terpenes, and others. Reactions that have been published in the literature using DMAP fall into, but are not limited to, the following types of reactions: Acylation; Acetylation; Alkylation; Benzoylation; Bischler-Naperalski cyclization, Carbonylation; Carbo-diimidation; Cyclization; Dehydration; Esterificaton; Indole Synthesis; Nucleophilic Substitution; Rearrangement; Silylation; Sulfonamidation; Sulfonation; Tritylation; Formylation; Carbamoylation; Phosphorylation; Lactonization; Pivaloylation; Dakin-West Reaction; Baylis-Hillman Reaction.
Chemical Properties    DMAP (m.p. 112-113°C) and PPY (m.p. 57-58°C)[4] are colorless, crystalline substances which are very soluble in methanol, ethyl acetate, chloroform, methylene chloride, 1,2-dichloroethane, acetone, and acetic acid and less soluble in cold hexane, cyclohexane, and water. DMAP can be recrystallized from ethyl acetate and PPY from pentane or hexane. The basicities of DMAP[5] and PPY in water as well as the dipole moment of DMAP[7-9] in benzene and dioxane have been determined by several groups. Of especial interest are the thermodynamic investigations concerned with the protonation of DMAP in water[11] and calculations whereby the influence of substituents on the basicity has been determined[6, 9, 10].


Uses    A highly efficient catalyst for acylation reactions.
Uses    4-Dimethylaminopyridine is a versatile hypernucleophilic acylation catalyst, it is used to improve the yield, reduce the reaction time, improving relaxation process conditions. Widely used in perfumes, dyes, pigments, pesticides, pharmaceuticals and polymer compounds and other fields. Also used as a catalyst for the synthesis of polyurethane, a curing agent and a blowing catalyst.
Uses    DMAP is a useful highly basic nucleophilic catalyst for a variety of reactions such as esterifications with anhydrides, the Baylis-Hillman reaction, hydrosilylations, tritylation, the Steglich rearrangement.
Uses    In a wide variety of organic syntheses as a catalyst.
Uses    A highly fluorescent adenosine analogue, which in a dimethoxytrityl, phosphoramidite protected form, can be site-specifically inserted into oligonucleotides through a 3?5?phosphodiester linkage using an automated DNA synthesizer
Purification Methods    Recrystallise DMAP from toluene [Sadownik et al. J Am Chem Soc 108 7789 1986]. [Beilstein 22 V 112.] § A polystyrene supported version (PS-DMAP) is commercially available.
4-Dimethylaminopyridine Preparation Products And Raw materials
Preparation Products    BETA-(4-ACETOXYPHENYL)PROPIONIC ACID-->2-Chloro-4-(trifluoromethyl)pyrimidine-->1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE-->1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-->N4-Benzoylcytosine-->3-Hydrazinyl-1-(4-methylpiperazin-1-yl)propan-1-one -->4-BROMO-5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-->2-ACETAMIDOPYRIDINE-3-CARBOXYLIC ACID-->3-Hydrazinyl-1-morpholinopropan-1-one -->2-Hydrazinyl-1-(4-methylpiperazin-1-yl)ethanone -->1-TERT-BUTYL-4-BROMO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-->2-Hydrazinyl-1-morpholinoethanone -->1-(2-PYRROLIDINOETHYL)PIPERAZINE-->4-BROMO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-->2-AMINO-ISONICOTINIC ACID ETHYL ESTER-->1-TERT-BUTYL-4-BROMO-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-->5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE-->4-TRIFLUOROMETHYL-N-METHYLANILINE 97-->Aniracetam-->Docetaxel-->(2R)-(-)-Glycidyl tosylate-->METHYL 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINATE-->2-Hydroxy-4-(trifluoromethyl)pyrimidine-->TERT-BUTYL 5-FORMYLTHIAZOL-2-YLCARBAMATE-->1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBALDEHYDE-->4-BROMO-5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-->1-ACETYL-5-BROMOINDOLINE-->4-AMINOBENZANILIDE-->2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE-->Boc-L-beta-Homoproline-->1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-->2'-BROMOACETANILIDE-->1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-->2-Aminoisonicotinic acid -->2,2,2-TRIFLUORO-1-(3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)ETHANONE-->5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-->LIMAPROST-->PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER-->MONO-METHYL SUCCINATE
Raw materials    Azabenzene-->Hexamethylphosphoramide-->4-Hydroxypyridine

Company Profile Introduction

Over 30 years experience in the chemical industry, Chemwill Asia Industrial co.,Ltd is one of the leading GMP complied manufacturer of Organic compounds in CHINA. Our main production base is located in Jiangsu province. We produce a wide range of organics including Active pharmaceutical ingredients(APIs), Veterinary, Indole derivatives, Aromatics, Fluorine, Boronic acids, organocatalysts, chiral building blocks, heterocyclic compounds. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place. Our advantageous business including: - Intermediate using for Pharmaceuticals - Active ingredient for Pharmaceutical and animal health (Human APIs and Veterinary APIs) - Fluorine, boronic acids, unnatural amino acids, cross linkers,chiral building blocks - Intermediate using for advanced performance materials - Monomer & polymers, high performance, photosensitive and specialty chemicals - Electro chemical materials(Lithium Battery, Photoresist, semiconductor, IT-related chemicals) * Custom synthesis from the laboratory scale to commercial production. * Contract research, custom manufacturing and contract-manufacture Ms Ella Lee - Deputy Sales Manager Phone: +86 -21-51086038 Email: chemwill_asia@126.com;chemwill@hotmail.com To learn more about our factory, PLS visit: www.chemwill.com

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