1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

Product Name:

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

Synonyms:

105628-72-6;1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE;HA 1100 HYDROCHLORIDE;1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-;Ha 1100;Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine;1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol

CAS:

MF:

C14H17N3O3S

MW:

307.36808

EINECS:

 

Product Categories:

Angiogenesis and Metastasis;Intracellular signaling

Mol File:

105628-72-6.mol

 

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Chemical Properties

storage temp. 

Store at -20°C

 

Safety Information

MSDS Information

 

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Usage And Synthesis

Biological Activity

Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .