Jatrorrhizine chloride NEW
| Price | $31 | $51 | $92 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-22 |
Product Details
| Product Name: Jatrorrhizine chloride | CAS No.: 6681-15-8 |
| Purity: 99.79% | Supply Ability: 10g |
| Release date: 2025/12/22 |
Product Introduction
Bioactivity
| Name | Jatrorrhizine chloride |
| Description | Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons. |
| In vitro | Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters. Jatrorrhizine chloride significantly inhibits the PMAT-mediated MPP+ uptake in a concentration-dependent manner (IC50: 1.05 μM). Jatrorrhizine chloride demonstrates a more powerful inhibition on 5-HT and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.68 mM), Sonication is recommended. DMSO : 8 mg/mL (21.4 mM), Sonication is recommended. |
| Keywords | Yatrorhizine Chloride | Serotonin Receptor | quaternary isoquinoline | PMAT | OCT | neuroprotective | Neprotine Chloride | Jatrorrhizine chloride | Jatrorrhizine Chloride | Jatrorrhizine | Inhibitor | inhibit | falciparum | E. histolytica | depressive disorder | Cytotoxic | Cholinesterase (ChE) | Bacterial | antiplasmodial | antioxidant | antimicrobial | antidepressant-like | antidepressant | antiamoebic | Alzheimer's disease | alkaloid | AChE | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Copper(Ⅱ) Sulfate | Doxycycline | Dimethyl sulfoxide | Sodium diacetate | BES |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Alkaloid Natural Product Library | Antiparasitic Natural Product Library | Neuroprotective Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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