Product Details
| Product Name:
Ac-FLTD-CMK |
CAS No.:
2376255-48-8 |
| Purity:
95.17% |
Supply Ability:
10g |
| Release date:
2025/11/09 |
Product Introduction
Bioactivity
| Name | Ac-FLTD-CMK |
| Description | Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects on caspases-1, caspases-4 and caspases-11 with IC50s of 46.7 nM, 1.49 μM and 329 nM, respectively. Ac-FLTD-CMK showed potency against caspases-1, caspases-4 and caspases-11, but not against apoptosis-associated caspase-3. |
| In vitro | Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (5.8 mM), Sonication is recommended.
DMSO : 90.0 mg/mL (158.2 mM), Sonication is recommended.
|
| Keywords | caspase-4 | caspase-11 | caspase-1 | Ac-FLTD-CMK | AcFLTDCMK | Ac FLTD CMK |
| Inhibitors Related | Disulfiram | 10-Hydroxydecanoic Acid | Ascorbyl palmitate | Hydralazine hydrochloride | Ethyl pyruvate | Berberine hydrogen sulphate | Cystamine dihydrochloride | (Iso)-Z-VAD(OMe)-FMK | Benzbromarone | Tauroursodeoxycholate | Berberine sulfate | Cinchonine |
| Related Compound Libraries | Apoptosis Compound Library | Cysteine Covalent Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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