ADU-S100 disodium salt NEW
| Price | $535 | Get Latest Price | Get Latest Price |
| Package | 5mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: ADU-S100 disodium salt | CAS No.: 1638750-95-4 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | ADU-S100 disodium salt |
| Description | ADU-S100 (MIW815) disodium salt is an activator of stimulator of interferon genes (STING). |
| Cell Research | Cryopreserved hPBMCs are thawed and 1×10^6 cells per well are plated in a 96 well plate in RPMI media supplemented with 10% FBS, 1% non-essential amino acids, 1% penicillin/streptomycin, L-glutamine, 10 mM HEPES buffer, 1 mM Sodium Pyruvate, 0.055 mM β-ME at 37°C with 5% CO2. Cells are stimulated with 10 μM ADU-S100 or ML cGAMP for 6 hours and supernatants are harvested. Supernatants are diluted 1:2 and assayed for IFN-α protein using Cytometric Bead Array (CBA) Human Flex Set. Data is collected using a FACSVerse cytometer. |
| Animal Research | WT C57BL/6 mice are inoculated with 5×10^4 B16.F10 cells in the left flank (n=8). When tumor volumes are 100 mm3 mice receive three IT doses of either ML RR-S2 CDG (25 μg), ADU-S100 (50 μg), or HBSS as control. WT C57BL/6 mice are inoculated with 5×10^4 B16.F10 cells in the left flank (n=5). When tumor volumes are 100 mm3 they received three IT doses of ADU-S100 at 5, 25, 50, or 100 μg or HBSS as control. WT C57BL/6 mice are inoculated with 5×104 B16.F10 cells in the left flank (n=8). When tumor volumes are 100 mm3 they receive three IT doses of 100 μg ADU-S100 or HBSS as control. Treatments are administered on days 13, 17, and 20 and tumor measurements are taken twice weekly. Results are shown as percent survival by Log-rank (Mantel-Cox) test (A and C). |
| In vitro | ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP. |
| In vivo | ADU-S100 demonstrates superior anti-tumor efficacy compared to the endogenous molecule ML cGAMP. Upon conducting a dose-response analysis in B16 tumor-bearing mice with the ADU-S100 compound, an optimal dose for maximal antitumor activity was identified. This optimal dose not only elicits heightened tumor antigen-specific CD8+ T cell responses but also significantly enhances long-term survival rates to 50%. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 300 mg/mL (408.44 mM), Sonication is recommended. |
| Keywords | STING | ML RR-S2 CDA disodium | ML RR-S2 CDA | MIW815 disodium | MIW-815 | MIW815 | MIW 815 | ADU-S-100 disodium salt | ADUS100 disodium salt | ADU-S100 disodium | ADU-S-100 | ADU-S100 | ADU-S 100 | ADU S100 disodium salt |
| Inhibitors Related | 2',3'-cGAMP sodium | SR-717 | H-151 | ChX710 | SN-008 | Vadimezan | Dazostinag disodium | C-176 | Cridanimod | CCCP | MSA-2 | C-178 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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