Alisertib Sodium NEW
| Price | $238 | $357 | $536 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-05 |
Product Details
| Product Name: Alisertib Sodium | CAS No.: 1028486-06-7 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2025/11/05 |
Product Introduction
Bioactivity
| Name | Alisertib Sodium |
| Description | Alisertib Sodium (MLN 8237 Sodium)is a selective Aurora A inhibitor that causes G2/M phase arrest and chromosomal misalignment, leading to tumour cell apoptosis, and can also inhibit STAT3 Tyr705 phosphorylation, resulting in downregulation of c-Myc expression. |
| In vitro | Methods: The anti-proliferative activity of Alisertib Sodium (MLN 8237 Sodium) was evaluated in various tumor cell lines. Cells were treated with the compound in vitro, and cell proliferation was measured to determine IC₅₀ values. Results: Alisertib Sodium exhibited significant anti-proliferative effects across different tumor cell lines, with IC₅₀ values ranging from 15 to 469 nM, indicating cell line-dependent sensitivity differences [4]. |
| In vivo | Methods: To investigate the inhibitory effect of Alisertib Sodium (MLN 8237 Sodium) on colorectal tumor growth, a HCT-116 colon cancer xenograft model was established in nude mice. Mice were administered Alisertib orally at doses of 3, 10, or 30 mg/kg once daily for 3 consecutive weeks. Results: Alisertib Sodium significantly inhibited tumor growth in a dose-dependent manner. The tumor growth inhibition (TGI) rates for the 3, 10, and 30 mg/kg groups were 43.3%, 84.2%, and 94.7%, respectively [4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Keywords | Alisertib sodium |
| Inhibitors Related | Stavudine | Aceglutamide | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Tributyrin | Paeonol | Naringin | L-Ascorbic acid sodium salt | Alginic acid | Gefitinib |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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