ALK/ROS1-IN-1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-19 |
Product Details
| Product Name: ALK/ROS1-IN-1 | CAS No.: 2365497-07-8 |
| Supply Ability: 10g | Release date: 2025/07/19 |
Product Introduction
Bioactivity
| Name | ALK/ROS1-IN-1 |
| Description | ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme). |
| In vitro | ALK/ROS1-IN-1 (compound 2e) displays potent anti-proliferative activity against ALK-addicted H3122 (IC50: 6.27 μM) and ROS1-addicted HCC78 cell lines (IC50: 10.71 μM). ALK/ROS1-IN-1 shows impressive enzyme activity against clinically Crizotinib-resistant ALKL1196M (IC50: 41.3 nM). ALK/ROS1-IN-1 shows potent inhibitory activity in Ba/F3 cell line expressing ROS1 mutants (IC50s: 137.7, 104.7 nM, and 233.9 for wide-type, G2032R mutant and L2026M mutant). ALK/ROS1-IN-1 has no significant effect on inducing apoptosis of the HCC78 cell line. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | ROS1 | ALK/ROS1-IN-1 | ALK/ROS-1-IN-1 | ALK/ROS1IN1 | ALK/ROS1 IN 1 | ALK |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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