Alvameline NEW
| Price | $2870 | $4590 | $7344 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-28 |
Product Details
| Product Name: Alvameline | CAS No.: 120241-31-8 |
| Supply Ability: 10g | Release date: 2025/10/28 |
Product Introduction
Bioactivity
| Name | Alvameline |
| Description | Alvameline (Lu25-109) is a partial M1 agonist and an M2/M3 antagonist. |
| In vitro | Alvameline undergoes metabolism in human liver microsomes, predominantly transforming into Lu 31-126 via CYP2D6. It also metabolizes into Lu 29-297 and Lu 25-077 primarily through CYP1A2, CYP2A6, CYP2C19, and CYP3A4, and into Lu 32-181 via CYP1A2 and possibly CYP2C19. Notably, the metabolite Lu 32-181 can be converted back into alvameline, a process unaffected by the presence of cytochrome P-450 inhibitors[1]. |
| In vivo | Alvameline has demonstrated efficacy in enhancing cognitive functions in rats after traumatic brain injury and exhibits concentration-dependent antagonism of carbachol-induced contractions in human and pig detrusor muscles, with pKb values of 6.2 in humans and 5.8 in pigs. Specifically, it competitively inhibits carbachol and electrically induced contractions in human detrusor muscle, while also causing significant decreases in the medial septal nucleus, vertical limb nucleus of the diagonal band, and nucleus basalis magnocellularis in treated rats by up to 13%, 48%, and 51%, respectively. Additionally, alvameline nearly completely blocks electrically stimulated contractions in human detrusor at 100 μM concentration but is less effective in pig detrusor, achieving a maximum inhibition of 32% at the same concentration. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Alvameline |
| Inhibitors Related | Adiphenine hydrochloride | (+)-Sparteine | Ethyl (triphenylphosphoranylidene) acetate | Clozapine N-Oxide | Pilocarpine nitrate | Urethane | Ribavirin | Adenine | Dibucaine | Choline chloride | Propoxur | Pempidine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $2870.00/25mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-08-21 | |
| $4590.00/50mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-08-21 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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