AS-85 NEW
| Price | $139 | $413 | $689 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-03 |
Product Details
| Product Name: AS-85 | CAS No.: 2323623-80-7 |
| Purity: 98.96% | Supply Ability: 10g |
| Release date: 2025/10/03 |
Product Introduction
Bioactivity
| Name | AS-85 |
| Description | AS-85 is a cell permeable ASH1L inhibitor with anti-leukemic activity, inhibits the growth of leukemic cells, increases cLogP, decreases tPSA, and can be used in the study of leukemia. |
| In vitro | AS-85 is a potent inhibitor of ASH1L histone methyltransferase with an IC50 of 0.6 µM and significant antileukemic activity.AS-85 binds tightly to the SET domain of ASH1L with a Kd value of 0.78 µM. AS-85 inhibits the proliferation of leukemia cells harboring different MLL1 translocations such as MV4;11, MOLM13 and KOPN8. AS-85 inhibited the proliferation of leukemia cells carrying different MLL1 translocations (e.g. MV4;11, MOLM13 and KOPN8) with GI50 values ranging from 5 µM to 25 µM, but did not have a significant effect on K562 leukemia cells without the MLL1 translocation. [1] |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (138.01 mM), Sonication is recommended. |
| Keywords | AS-85 | AS 85 |
| Inhibitors Related | MAK-683 hydrochloride | BIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | MAK683 | EPZ015666 | iso-Azalansta | AMI-1 free acid | MS37452 | MRTX-1719 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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