Asciminib hydrochloride NEW
| Price | $139 | $197 |
| Package | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-05 |
Product Details
| Product Name: Asciminib hydrochloride | CAS No.: 2119669-71-3 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2025/12/05 |
Product Introduction
Bioactivity
| Name | Asciminib hydrochloride |
| Description | Asciminib hydrochloride is described as a "STAMP inhibitor," specifically targeting the ABL myristoyl pocket, Asciminib hydrochloride, marketed as Scemblix, are applied in research in Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) by binding to the allosteric site of wild-type ABL N-terminus, which is myristoylated, whereas the ABL fusion protein lacks this domain, enabling selective modulation of oncogenic signaling pathways and serving as a targeted therapeutic tool in hematologic cancer research. |
| In vitro | Pretreatment with Asciminib hydrochloride (0.5 μM) for 1 hour did not interfere with the DNA damage response signaling induced by 4-OH-Cy in MCF7 cells. Compared to the 4-OH-Cy treatment alone group, the Asciminib hydrochloride pretreatment group showed no significant differences in the expression levels of DNA damage marker proteins such as phosphorylated ATM (p-ATM), γH2AX, and phosphorylated p53 [2]. Parazacco spilurus subsp. spilurus [2]. |
| In vivo | In animal experiments conducted on young mice (P6-P7 days old), a combined treatment of Asciminib hydrochloride (0.1–0.5 mg/kg) and cyclophosphamide (100 mg/kg) was administered via intraperitoneal injection to evaluate its protective effects on ovarian reserve. The experimental results demonstrated that Asciminib hydrochloride at a dose of 0.25 mg/kg significantly alleviated Cy-induced DNA damage stress signaling, manifested by the inhibition of TAp63 protein modification, reduced expression of DNA damage response markers such as γH2AX and phosphorylated DNA-PK, and decreased activation of cleaved PARP in oocytes. Additionally, Asciminib hydrochloride suppressed Akt phosphorylation in follicular reserve cells, indicating its regulatory role in Cy-triggered excessive follicular activation [2. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble) DMSO : 80 mg/mL (164.51 mM), Sonication is recommeded. |
| Inhibitors Related | Imatinib Mesylate | Pivanex | Bosutinib hydrate | Dasatinib | GNF-5 | Vodobatinib | Berbamine dihydrochloride | Nilotinib monohydrochloride monohydrate | KW-2449 | Rebastinib | Imatinib | Nocodazole |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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