ATP NEW
| Price | $34 | $48 | $78 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: ATP | CAS No.: 56-65-5 |
| Purity: 98.87% | Supply Ability: 10g |
| Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | ATP |
| Description | ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specific purinergic receptors to mediate a variety of processes including neurotransmission, inflammation, apoptosis, and bone remodeling. |
| In vitro | METHODS: Synovial fibroblast HSF were rapidly treated (wash-in and wash-out ~2 s) with ATP (10 μM) three times, and [Ca2+] changes were detected using Fluo-4 fluorescence. RESULTS: During the first application of ATP, Fluo-4 fluorescence increased rapidly after a delay of a few seconds and decreased slightly before the end of ATP application. After removal of ATP, the fluorescence signal returned to resting levels, but fluorescence decreased much more slowly than it had begun after the initial ATP application. The two subsequent ATP applications produced a response of less amplitude than the first, and the delay until the onset of the response appeared to lengthen with successive applications. [1] METHODS: Mouse bone marrow-derived macrophages BMDM were stimulated with LPS, HKEC, or HKSA, followed by treatment with ATP (2 mM) for 0.5-24 h. Levels of IL-1β, KC, and MIP-2 were determined using ELISA. RESULTS: ATP treatment strongly induced the secretion of IL-1β, KC and MIP-2. [2] |
| In vivo | METHODS: To test the antibacterial activity in vivo, ATP (50 mg/kg) was injected intraperitoneally into Kunming mice, and E. coli 25922 or S. aureus 25923 was injected 1-24 h later. RESULTS: The administration of ATP 4 h or 24 h before the attack did significantly increase the survival rate of infected mice, regardless of the bacterial type. [2] METHODS: To assay in vivo antibacterial activity, ATP (40 mg/kg), clarithromycin (12 mg/kg), and rifampin (8 mg/kg) were injected subcutaneously into MAC-infected BALB/c mice five times per week for eight weeks. RESULTS: Co-administration of ATP with clarithromycin and rifampin accelerated bacterial clearance in MAC-infected mice without resulting in changes in histopathologic features or mRNA expression of pro- or anti-inflammatory cytokines in mice not given ATP. [3] |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 1.67 mg/mL (3.29 mM), Sonication is recommended. H2O : 100 mg/mL (197.17 mM), Sonication is recommended. |
| Keywords | EndogenousMetabolite | Endogenous Metabolite | Adenosine 5'-triphosphate |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Chinese Pharmacopoeia Natural Product Library | Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Mouse Metabolite Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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