AZ-PFKFB3-67 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: AZ-PFKFB3-67 | CAS No.: 1704741-11-6 |
| Supply Ability: 10g | Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | AZ-PFKFB3-67 |
| Description | AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with an IC50=11nM for PFKFB3, reduces MCL-1, and inhibits angiogenesis by decreasing lactic acid production and ATP levels in endothelial cells (ECs) in tube-forming assays, and has neuroprotective effects. |
| In vitro | AZ-PFKFB3-67 is a highly selective PFKFB3 inhibitor with strong target inhibitory activity, exhibiting IC₅₀ values of 1.13 μM for PFKFB1, 0.159 μM for PFKFB2, and 0.011 μM for PFKFB3. In cellular assays, AZ-PFKFB3-67 inhibits fructose-2,6-bisphosphate (F-2,6-BP) production with an IC₅₀ of 0.281 μM, while having minimal effect on cellular lactate levels (IC₅₀ > 30 μM), indicating a pronounced inhibitory effect on early glycolytic regulation[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.39 mM), Sonication is recommended. DMSO : 80 mg/mL (175.63 mM), Sonication is recommended. |
| Keywords | AZ-PFKFB3-67 | AZ-PFKFB-3-67 | AZPFKFB367 | AZ PFKFB3 67 |
| Inhibitors Related | Cyanoacetamide | Ascorbyl palmitate | (S)-(+)-Ibuprofen | Amantadine | Hydralazine hydrochloride | Estradiol benzoate | Navitoclax | D-(-)-3-Phosphoglyceric acid disodium | Oxfendazole | Venetoclax | Benzbromarone | Thymoquinone |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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