Product Details
| Product Name:
AZ32 |
CAS No.:
2288709-96-4 |
| Purity:
99.94% |
Supply Ability:
10g |
| Release date:
2025/05/30 |
Product Introduction
Bioactivity
| Name | AZ32 |
| Description | AZ32 is an orally bioavailable, blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for the ATM enzyme and an IC50 of 0.31 μM for ATM in cells. |
| In vitro | AZ32 is an enhanced blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro[1]. |
| In vivo | AZ32 exhibits superior blood-brain barrier (BBB) penetration and is more effective as a radiosensitizer in both syngeneic and human orthotopic mouse glioma models compared to AZ31. It acts as a specific inhibitor of the ATM kinase, showcasing commendable BBB penetration in mice. A single oral dose of AZ32 (200 mg/kg) maintains free-brain concentrations above the cellular IC50 for around 22 hours [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (167.49 mM), Sonication is recommended.
|
| Keywords | Inhibitor | inhibit | AZ-32 | AZ32 | AZ 32 | ATR | ATM/ATR | ATM and RAD3 related | ATM | Ataxia telangiectasia mutated |
| Inhibitors Related | CP-466722 | Ro 90-7501 | AZ31 | Dactolisib | Berzosertib | Elimusertib | GJ103 sodium salt | KU60019 | Ceralasertib | (Z)-Mirin | NU6027 | Schisandrin B |
| Related Compound Libraries | Neural Regeneration Compound Library | Glycolysis Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | CNS-Penetrant Compound Library | Inhibitor Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States