Product Details
| Product Name:
AZD4721 |
CAS No.:
1418112-77-2 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | AZD4721 |
| Description | AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 ( CXCR2 ). AZD4721 has the potential for the research of inflammatory disease. |
| In vivo | This study evaluates the pharmacokinetic (PK) profile of AZD4721 (RIST4721) in rats and dogs. It provides a comparison of predicted and observed clearance (CL) rates, including hepatic metabolic CL, observed CL, renal CL, and biliary CL, measured in ml/min per kilogram. Additionally, it assesses the in vivo/in vitro unbound CL, steady-state volume distribution (V SS) measured in l/kg, half-life (T 1/2) in hours, and oral bioavailability (F %). The findings reveal differences in the pharmacokinetic behavior between the two species, with noted values in rats being a predicted hepatic metabolic CL of 1.7 and an observed CL of 2.4, while in dogs, these values are 0.80 and 0.50 respectively. Renal and biliary CL were found to be less than 0.01 in rats and slightly higher in dogs. In vivo/in vitro unbound CL, V SS, and T 1/2 also differ, with rats showing a faster metabolism and clearance compared to dogs. The oral bioavailability is 45% in rats and 82% in dogs. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | RIST-4721 | RIST 4721 | AZD-4721 | AZD 4721 |
| Inhibitors Related | AZD8309 | rac-NBI-74330 | Delmetacin | Tannic acid | Artemotil | SB225002 | CXCR2-IN-1 | Plerixafor octahydrochloride | SX-682 | Nicotinamide N-oxide | Plerixafor | CXCL-CXCR1/2-IN-1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
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Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States