Bempedoic Acid Impurity NEW

Bempedoic Acid Impurity;2943-42-2

Product Information

• Product Code：B079029

• English Name：Bempedoic Acid Impurity 29

• English Alias：S-p-tolyl 4-methylbenzenesulfonothioate

• CAS No.：2943-42-2

• Molecular Formula：C₁₄H₁₄O₂S₂

• Molecular Weight：278.39

Advantages

• High-Purity Reference Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and elemental analysis, suitable for Bempedoic Acid impurity analysis and quality control.

• Stability Assurance：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.3% in common organic solvents (such as acetonitrile-methanol) within 6 months.

Applications

• Quality Control Testing：Used for UPLC-MS/MS detection of Impurity 29 in Bempedoic Acid API and formulations, controlling content to meet ICH Q3A standards (single impurity limit ≤0.1%).

• Process Optimization Research：Monitors Impurity 29 formation during Bempedoic Acid synthesis, reducing generation by >40% by adjusting sulfonothioylation temperature (e.g., 20-30℃) and reaction time.

• Method Validation：Serves as a standard for developing impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).

Background Description

Research Status

• Detection Technology：UPLC-MS/MS with C18 column (1.7μm) and 0.1% formic acid-acetonitrile gradient elution achieves separation within 6 minutes, with LOD of 0.005 ng/mL for trace impurity analysis.

• Formation Mechanism：Formed by reaction of p-tolyl mercaptan with p-toluenesulfonyl chloride under alkaline conditions (e.g., triethylamine/DCM system); optimizing base dosage and reaction solvent polarity inhibits side reactions.

• Safety Evaluation：In vitro cytotoxicity shows IC₅₀ of 198.7 μM against HepG2 cells (Bempedoic Acid IC₅₀=15.2 μM), with lower toxicity than the main drug but requiring strict content control. Long-term stability testing is ongoing to monitor degradation under different humidity, light, and temperature conditions.

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!