BIIL-260 hydrochloride NEW
| Price | $778 | $1190 | $1880 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: BIIL-260 hydrochloride | CAS No.: 192581-24-1 |
| Purity: 98.89% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | BIIL-260 hydrochloride |
| Description | BIIL-260 hydrochloride is an orally active and highly efficient leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, inhibiting LTB4-induced intracellular Ca2+ release in human neutrophils. |
| In vitro | BIIL-260 hydrochloride binds to the LTB4 receptor in a reversible, competitive and saturable manner, exhibiting high affinity for the LTB4 receptor on isolated human neutrophil membranes, with a Ki value of 1.7 nM.In addition, BIIL-260 hydrochloride significantly inhibits LTB4-induced intracellular calcium release in human neutrophils, with an IC50 value of 0.82 nM. [1] |
| In vivo | In a monkey model, a single oral dose of 0.3 mg/kg of BIIL-260 hydrochloride completely inhibited LTB(4) receptor activity within 24 hours by detecting LTB(4)-induced neutropenia or Mac1 expression. [1] |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (198.8 mM), Sonication is recommended. |
| Keywords | NOP | MOP | LTB4 receptor1110 | BIIL-260 Hydrochloride |
| Inhibitors Related | Montelukast sodium | LTB4-IN-1 | L 674573 | Olsalazine disodium | Desloratadine | CGP 35949 | Bestatin | Tebufelone | ABT-080 | LTβR-IN-1 | Darbufelone mesylate | Ticolubant |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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