Product Details
| Product Name:
BMS453 |
CAS No.:
166977-43-1 |
| Purity:
99.93% |
Supply Ability:
10g |
| Release date:
2025/11/10 |
Product Introduction
Bioactivity
| Name | BMS453 |
| Description | BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ. |
| In vitro | BMS453 (1 μM; 11 hours; 184 and HMEC cells) inhibits normal breast cell proliferation without significantly inducing apoptosis[2]. The RARβ-selective agonist (BMS453) significantly reduces T47D breast cancer cell migration to levels comparable to RA inhibition, unlike RARα- or RARγ-selective agonists (BMS753 and BMS961), indicating RARβ's role in RA-inhibited cell migration[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (118.27 mM), Sonication is recommended.
|
| Keywords | TGFβ | RetinoidReceptor | Retinoid X receptors | Retinoid Receptor | retinoid | Retinoic acid receptors | RARγ | RARβ | RARα | RAR/RXR | Inhibitor | inhibit | cell | breast | BMS-453 | BMS453 | BMS189453 | BMS 189453 | arrest |
| Inhibitors Related | Isotretinoin | Adapalene | Oxybenzone | MSU-42011 | Tazarotene | Etodolac | ER 50891 | Acitretin | Tamibarotene | Bexarotene | TTNPB | K-8012 |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Cancer Cell Differentiation Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States