Product Details
| Product Name:
BPI-9016M |
CAS No.:
1528546-94-2 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | BPI-9016M |
| Description | BPI-9016M is an effective, orally active, and selective dual inhibitor of c-Met and AXL tyrosine kinases. It suppresses tumor cell growth, invasion, and migration of lung adenocarcinoma. |
| In vitro | The IC50 of BPI-9016M in several lung adenocarcinoma cell lines ( A549, H1299, H1650, H1975, HCC827, and PC-9 cells) as well as in primary lung adenocarcinoma cells are ranged from 5.3 μM to 27.1 μM. BPI-9016M (3.1-50 μM) reduces the expression of c-Met, p-c-Met, p-AKT, and p-ERK in the H1299 and A549 cells in a dose-dependent manner. BPI-9016M (6.3-25 μM; 2 weeks) inhibited cell proliferation. BPI-9016M (12.5-50 μM; 24 hours) induces the accumulation of more tumor cells in the G1 phase [2]. |
| In vivo | In PDX xenografts in NOD/SCID mice, BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | BPI9016M | BPI 9016M | BPI-9016M |
| Inhibitors Related | Cabozantinib | (S)-Afatinib | (Z)-Semaxinib | BMS-754807 | Decanoic Acid | L-Ascorbic acid 2-phosphate trisodium | Afatinib Dimaleate | Crizotinib | 7-Methoxy-1-tetralone | Tepotinib | Afatinib | Cabozantinib S-malate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$3100.00/100mg |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-08-21 |
United States