Product Details
| Product Name:
Capsiate |
CAS No.:
205687-01-0 |
| Purity:
99.24% |
Supply Ability:
10g |
| Release date:
2025/10/26 |
Product Introduction
Bioactivity
| Name | Capsiate |
| Description | Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity. |
| In vitro | Capsiate elicits current responses in HEK293 cells expressing TRPV1[3]. Additionally, Capsiate (5 to 25 µM) inhibits Src and VEGF-induced proliferation and tube formation in human umbilical vein endothelial cells (HUVECs)[1]. |
| In vivo | Capsiate (0.03~0.54 mM; s.c.) induces nociceptive responses in mice.[3]
Topical application of Capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis.[3]
Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.[4] |
| Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90 mg/mL (293.73 mM), Sonication is recommended.
|
| Keywords | TRPVChannel | TRPV1 | TRPV Channel | TRPChannel | TRP Channel | Capsiate | Antioxidant |
| Inhibitors Related | Rosiglitazone | Caffeic Acid | Butylated hydroxytoluene | AFMK | Probenecid | L-Tartaric acid | Neohesperidin | Sulbutiamine | L-Cystine | trans-Cinnamaldehyde | 4-hydroxyphenylacetic acid | Trolox |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Pain-Related Compound Library | Rare Natural Product Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Drug Repurposing Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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