CDK5 inhibitor 20-223 NEW
| Price | $95 | $789 | $1180 |
| Package | 2mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-21 |
Product Details
| Product Name: CDK5 inhibitor 20-223 | CAS No.: 865317-30-2 |
| Supply Ability: 10g | Release date: 2025/08/21 |
Product Introduction
Bioactivity
| Name | CDK5 inhibitor 20-223 |
| Description | CDK5 inhibitor 20-223 （CP668863） is a potent CDK2/CDK5 inhibitor with IC50 values of 6.0 nm and 8.8 nM, respectively, with anti-Colorectal Cancer (CRC) potential, inhibiting cell migration and inducing cell cycle arrest in multiple CRC cell lines. |
| In vitro | CDK5 inhibitor 20-223 inhibits CDK2/CDK5 (IC₅₀ ≈ 362 nM), causes cell cycle arrest, reduces RB and FAK phosphorylation, and blocks CRC cell migration. CRC cell lines SW620, DLD1, HT29, HCT116, FET, CBS, and GEO cells[1]. |
| In vivo | In mice, CDK5 inhibitor 20-223 (8 mg/kg, 3 weeks) significantly reduced tumor growth without toxicity and lowered pFAK levels in tumors[1]. |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (261.98 mM), Sonication is recommended. |
| Inhibitors Related | Ribociclib | Ro-3306 | Abemaciclib | Rafoxanide | AT7519 | Palbociclib monohydrochloride | Nimbolide | GW 441756 | Sodium Oxamate | Seliciclib | Abemaciclib methanesulfonate | Dinaciclib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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