Celgosivir NEW
| Price | $357 | $786 |
| Package | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Celgosivir | CAS No.: 121104-96-9 |
| Purity: 98.03% | Supply Ability: 10g |
| Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Celgosivir |
| Description | Celgosivir (6 O-butanoyl castanospermine) is an inhibitor of α-glucosidase I. In vitro assay, it inhibits bovine viral diarrhoea virus (BVDV) ( IC50: 1.27 μM ). |
| In vitro | Celgosivir exhibits potent antiviral activity against HIV-1 (IC50: 2.0±2.3 μM) [1]. Celgosivir inhibits DENV2 replication (EC50: 0.2 μM). The EC50 values against DENV1, 3 and 4 are less than 0.7 μM[3]. Celgosivir is more effective (IC50=20 μM) than the parent molecule (IC50=254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Bovine viral diarrhoea virus (BVDV) is a closely related virus of hepatitis C virus (HCV). In plaque assay and cytopathic effect assay, Celgosivir inhibits BVDV, with IC50 values of 16 and 47 μM , respectively[2]. |
| In vivo | Celgosivir demonstrates robust protection in AG129 mice against lethal infection from a mouse-adapted dengue virus, effectively administered at a dosage of 50 mg/kg twice daily (BID) for a duration of 5 days. This protective efficacy is maintained even when treatment onset is delayed by 48 hours. The outcomes suggest that celgosivir's protective capability is contingent upon both the dosage and the administration schedule, with a twice daily regimen of 50, 25, or 10 mg/kg proving superior to a single daily dose of 100 mg/kg in terms of survival. Specifically, during primary infection with the mouse-adapted DENV strain S221, there is a notable increase in viremia by day 3. However, an impressive 80% of mice survive until day 10, with the virus being completely eliminated by day 8[3]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (192.83 mM), Sonication is recommended. H2O : 1.8 mg/mL (6.94 mM), Sonication is recommended. |
| Keywords | α-glucosidase I | α-glucosidase | MX-3253 | MX 3253 | MDL-28574 | MDL28574 | MBI-3253 | MBI3253 | Celgosivir |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Methyl 2-amino-5-bromobenzoate | Deferiprone | Lamivudine | Penicillin G potassium | Valproic Acid | (E)-3-(p-Tolyl)acrylaldehyde | 3-Hydroxypyridine | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Glycometabolism Compound Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | ReFRAME Related Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Inhibitor Library | Metabolism Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| $357.00/10mg |
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2025-10-20 | |
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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