CHMFL-ABL/KIT-155 NEW
| Price | $1670 | $2180 | $2800 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: CHMFL-ABL/KIT-155 | CAS No.: 2081093-21-0 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | CHMFL-ABL/KIT-155 |
| Description | CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis. |
| In vitro | CHMFL-ABL/KIT-155 also presents significant inhibitory activities to BLK, CSF1R, DDR1, DDR2, LCK and PDGFRβ (IC50s: 81 nM, 227 nM, 116 nM, 325 nM,12 nM, and 80 nM) kinases. CHMFL-ABL/KIT-155 exhibits anti-proliferation activities in the BCR-ABL dependent CML cancer cell lines such as MEG-01 (GI50: 0.02 μM), K562 (GI50: 0.027 μM), and KU812 (GI50: 0.056 μM). It also potently inhibits the growth of c-KIT dependent GISTs cancer cell lines including GIST-882 (GI50: 0.095 μM), GIST-T1 (GI50: 0.023 μM) but not c-KIT independent GIST-48B (GI50: 3.96 μM). |
| In vivo | In female nu/nu mice bearing established K562 tumor xenografts, CHMFL-ABL/KIT-155 (25-100 mg/kg; p.o.; once daily for 28 days) shows dose-dependent tumor progression suppression without apparent toxicity. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | type II ABL | PDGFRβ | LCK | DDR2 | DDR1 | CSF1R | c-KIT | cKit | CHMFL-ABL-KIT155 | CHMFL-ABL-KIT 155 | CHMFL-ABL/KIT-155 | CHMFL-ABL/KIT155 | CHMFLABL/KIT155 | CHMFL-ABL/KIT 155 | CHMFL ABL/KIT 155 | BLK |
| Inhibitors Related | Gilteritinib | Regorafenib monohydrate | Sorafenib | Pexidartinib | Dasatinib | Regorafenib | Ponatinib | Sorafenib tosylate | Lenvatinib mesylate | Imatinib | Pazopanib | Axitinib |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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