CK1-IN-2 NEW
| Price | $68 | $166 | $269 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: CK1-IN-2 | CAS No.: 1383376-92-8 |
| Purity: 99.31% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | CK1-IN-2 |
| Description | CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor with IC50 values of 123, 19.8, 26.8, and 74.3 nM for CK1a, CK1d, CK1e, and p38a, respectively, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy. |
| In vitro | CK1-IN-2 (compound No. 4) is a potent inhibitor of casein kinase 1 (CK1), with IC₅₀ values of 123 nM (CK1α), 19.8 nM (CK1a), 26.8 nM (CK1d), and 74.3 nM (CK1e), indicating subtype selectivity[1]. CK1-IN-2 (0.02-10 μM, 72 h) promotes myotube formation in FSHD (facioscapulohumeral muscular dystrophy) cells, indicating its role in enhancing muscle cell fusion[1]. At 10 μM (72 h), CK1-IN-2 is also capable of reversing the inhibitory effect of Losmapimod on myotube formation[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.47 mM), Sonication is recommended. DMSO : 40 mg/mL (129.33 mM), Sonication is recommended. |
| Keywords | CaseinKinase | Casein Kinase |
| Inhibitors Related | Adezmapimod | Exarafenib | Doramapimod | TBCA | Ellagic acid | Emodin | Bakuchiol | Asiatic acid | SB 202190 | (-)-Bornyl acetate | MW-150 | Nisin Z |
| Related Compound Libraries | Bioactive Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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