Product Details
| Product Name:
CLT-28643 |
CAS No.:
1153631-91-4 |
| Purity:
99.89% |
Supply Ability:
10g |
| Release date:
2025/11/10 |
Product Introduction
Bioactivity
| Name | CLT-28643 |
| Description | CLT-28643 is a potent and specific α5β1-Integrin inhibitor that prevents fibrosis in glaucoma filtration surgery (GFS), inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation in a bleomycin-induced lung fibrosis model, and improves insulin sensitivity and cardiac function in H9C2 cells from obese mice. |
| In vitro | In H9C2 cardiomyocytes, CLT-28643 (3 hours) was used to assess its effect on insulin signaling under metabolic stress, CLT-28643 prevented high glucose and palmitate-induced insulin resistance by significantly increasing the phosphorylated Akt (Ser473) to total Akt ratio, indicating restored insulin sensitivity. [1] |
| In vivo | In male C57BL/6 mice fed a high-fat-high-sucrose (HFHS) diet for 10 weeks, CLT-28643 (75 mg/kg; oral gavage; twice daily for 4 weeks) was administered to evaluate its cardiometabolic effect. CLT-28643 improved cardiac function by reversing the HFHS diet-induced elevation in heart rate, suggesting enhanced cardiovascular performance. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | ICI-204879 hydrochloride | ICI204879 HCl | ICI 204879 HCl | CLT-28643 | CLT 28643 |
| Inhibitors Related | K34c hydrochloride | E7820 | Arg-Gly-Asp TFA (99896-85-2(free base)) | Tirofiban hydrochloride monohydrate | Lifitegrast | Elarofiban TFA | Tirofiban | Bestatin hydrochloride | RO0270608 | ICAM-1-IN-1 | Cilengitide | Gantofiban |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States