CXCL-CXCR1/2-IN-1 NEW
| Price | $40 | $64 | $129 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: CXCL-CXCR1/2-IN-1 | CAS No.: 2415653-55-1 |
| Purity: 99.40% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | CXCL-CXCR1/2-IN-1 |
| Description | CXCL-CXCR1/2-IN-1 is an orally active and potent inhibitor of the ELR+CXCL-CXCR1/2 pathway with anticancer and anti-angiogenic activity and can be used to study cardiovascular disease and cancer. |
| In vitro | CXCL-CXCR1/2-IN-1 (compound 10; 1-2.5 μM; 24-48h; A498 cells) showed reduced ERK and AKT phosphorylation in A498 cells. CXCL-CXCR1/2-IN-1 also can inhibit the secretion of CXCL1, CXCL5, and CXCL8, which are representative pro-angiogenic ELR+CXCL cytokines.[1] |
| In vivo | CXCL-CXCR1/2-IN-1 (1 μM; 48h; Female NOD SCID mice injected with 786 RCC cells) reduces the metastatic area in zebrafish embryos injected with A498 cells.[1] CXCL-CXCR1/2-IN-1 (100 mg/kg; oral gavage; twice a day; for 28 days) inhibits tumor growth in mice.[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 2 mg/mL (5.22 mM), Sonication is recommended. |
| Keywords | CXCR | CXCLCXCR1/2IN1 |
| Inhibitors Related | AZD8309 | rac-NBI-74330 | Delmetacin | Tannic acid | Artemotil | SB225002 | CXCR2-IN-1 | JMS-17-2 | Plerixafor octahydrochloride | SX-682 | Nicotinamide N-oxide | Plerixafor |
| Related Compound Libraries | Bioactive Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Chemokine Inhibitor Library | Angiogenesis related Compound Library | Inhibitor Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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