Product Details
| Product Name:
CXL-1020 |
CAS No.:
950834-06-7 |
| Supply Ability:
10g |
Release date:
2025/10/27 |
Product Introduction
Bioactivity
| Name | CXL-1020 |
| Description | CXL-1020, a nitroxyl (HNO) prodrug, enhances cardiac inotropy/lusitropy and Ca 2+ cycling in rats exhibiting abnormal relaxation, induces vasorelaxation, and augments cardiac function in canine models. It has been investigated for its potential in treating systolic and stable heart failure [1]. |
| In vivo | CXL-1020, administered at a dosage of 100 μg/kg/min via a 30-minute infusion, significantly improves hemodynamics and cardiac functionality, enhancing both diastolic and systolic performance in mice [1]. Conversely, at dosages of 3 and 10 mg/kg/min through a 4-hour intravenous infusion, CXL-1020 elevates left ventricular systolic and diastolic functions in dogs suffering from advanced heart failure [2]. In an animal model using adult male Sprague-Dawley rats (250-350 g; with cardiac dysfunction induced by isoproterenol) [1], the administration of CXL-1020 at 100 μg/kg/min for 30 minutes noticeably improved hemodynamics and cardiac function in normal rats, and substantially boosted both diastolic and systolic performance in cardiac dysfunction mice. Similarly, in dogs with heart failure induced by coronary microembolization [2], dosages of 3 and 10 mg/kg/min resulted in a dose-dependent improvement in cardiac function, evidenced by a modest decrease in systolic aortic pressure (AoP), a significant increase in ejection fraction (EF) and early mitral inflow velocity deceleration time (DT), and a significant reduction in left ventricular end-systolic volume (ESV), end-diastolic pressure (EDP), and end-diastolic wall stress (EDWS). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Nisoldipine | 2,4,6-Tri-tert-butylphenol | Diltiazem hydrochloride | Praziquantel | Cromolyn sodium | L-Ascorbic acid | L-Phenylalanine | Ethyl cinnamate | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid | Cinchonine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$337.00/1mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-04-27 |
United States