Cyclo(Gly-L-Pro) NEW
| Price | $50 |
| Package | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-25 |
Product Details
| Product Name: Cyclo(Gly-L-Pro) | CAS No.: 3705-27-9 |
| Purity: 98.48% | Supply Ability: 10g |
| Release date: 2025/10/25 |
Product Introduction
Bioactivity
| Name | Cyclo(Gly-L-Pro) |
| Description | Cyclo(Gly-L-Pro), a cyclic dipeptide, demonstrates significant immunomodulatory activity by stimulating beneficial immune responses while simultaneously suppressing the release of the pro-inflammatory cytokine TNF-α, reducing mRNA expression of IL-1β and IL-6, and inhibiting nitric oxide (NO) production. it has also been shown to enhance memory and improve functional recovery in animal models, indicating substantial potential for neuroscience research due to its neuroprotective and immunostimulatory properties. |
| In vitro | Methods: CIK cells were stimulated with Cyclo(Gly-L-Pro) (1, 10, 100 μg/ml), and the expression of MyD88, IL-1β, TNF-α, I-IFN, and IL-8 genes at different time points (2, 8, and 24 h) after stimulation was quantified by real-time fluorescence. Lipopolysaccharide (LPS), a known immunostimulant, was used as a positive control. To analyze whether these compounds were toxic to the cells, changes in cell viability were measured using a methyltetrazole assay. Results: Cyclo(Gly-L-Pro) and LPS significantly increased the transcription level of MyD88 as early as 2 h after exposure; Cyclo(Gly-L-Pro) also induced the gene expression of cytokines such as IL-1β, TNF-α, and I-IFN. Under the experimental conditions, Cyclo(Gly-L-Pro) was not toxic to CIK cells. [1] |
| Storage | keep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 180 mg/mL (1167.54 mM), Sonication is recommended. DMSO : 20 mg/mL (129.73 mM), Sonication is recommended. |
| Keywords | Cyclo(Gly-L-Pro) |
| Inhibitors Related | Acetylcysteine | Isosteviol | Taxifolin | Acefylline | Glucosamine | Thalidomide | Apremilast | Pomalidomide | Lenalidomide | Fisetin | Linalool | Taurocholic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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