D-serine

CAS Number：

312-84-5

Chemical formula：

C₃H₇NO₃

Molecular weight：

105.09

HS code：

29225000

EINECS No：

206-229-4

English alias:

D-Ser；D-Serin；D-SERINE；D-Ser-OH

H-D-Ser-OH；D-(+)-Serine；β-Hydroxyalanine

D-2-Amino-3-Hydroxypropionic；

D-2-Amino-3-hydroxypropanoic acid；

(R)-2-AMINO-3-HYDROXYPROPIONIC ACID；

(R)-2-amino-3-hydroxypropanoic acid；

(2R)-2-amino-3-hydroxy-propanoic acid

Introduction

D-serine (D-serine) is an amino acid that, like L-serine, is converted from glutamic acid. D-serine plays an important neurotransmitter role in the central nervous system, particularly as a co-agonist of N-methyl-D-aspartate receptors (NMDAR).

In the human body, D-serine is mainly synthesized by glutamate dehydrogenase and serine esterase, and is mainly found in the brain and kidney. Its concentration in the human brain is lower than that of L-serine, but its concentration in neurons and glial cells is quite high. As an agonist of NMDAR receptors, D-serine is involved in a variety of physiological processes, including memory, learning, neural development, and pain perception. In addition, D-serine is also related to the occurrence of neuropsychiatric diseases, such as schizophrenia.

In general, D-serine, as an important neurotransmitter, is of great significance in neuroscience research.

Morphology and its properties

D-serine is a white crystalline powder, tasteless and odorless, easily soluble in water. It is a chiral molecule with one chiral center, and it is a stereoisomer of D-configuration, which is very similar to L-serine in chemical structure, except that their three-dimensional configuration is different.

D-serine is mainly synthesized in vivo by glutamate dehydrogenase and serine esterase, and its concentration in the human brain is lower than that of L-serine, but its concentration in neurons and glial cells is quite high. As an agonist of NMDA receptors, it can regulate the excitability and inhibition of neurons, and is involved in a variety of physiological processes, including learning, memory, neurodevelopment and pain perception.

D-serine is also a very stable compound that can exist stably under both acidic and alkaline conditions. In addition, it is not easy to be degraded by various enzymes, so its half-life in organisms is relatively long, which makes it have a longer acting time and a wider range of biological activities.

Quality Inspection

Project

Standard

Appearance

White crystal or crystalline powder

Assay(drying basis)

98.5%~100.5%

Transmittance

≥95.0%

Specification Rotation

-14.5°～-15.5°

pH value

5.2～6.2

Loss on drying

≤0.50%

Residue on Ignition

≤0.2%

Chloride

≤0.02%

Sulfate

≤0.02%

Heavy metal(Lead)

≤10ppm

Ironic(Fe)

≤10ppm

Arsenic(As)

≤1ppm

Ammonium(NH4)         

≤0.02%

Other amino acids

≤0.5%

Package: In 25 kg net per fiber drum, inner polythene bags. We can provide the packing as you requested.