Deucravacitinib Impurity6 NEW

Deucravacitinib Impurity6;1609393-48-7

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E-mail: anna@molcoo.com

Product Information

• Product Code：D084006

• English Name：Deucravacitinib Impurity 6

• English Alias：6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide

• CAS No.：1609393-48-7

• Molecular Formula：C₁₉H₁₇D₃N₈O₃

• Molecular Weight：411.43

Advantages

• High-Purity Isotopic Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C, DEPT), HRMS (isotope peak analysis), and elemental analysis, with ≥99% deuterium labeling (methyl-d3), providing an accurate isotopic internal standard for Deucravacitinib impurity analysis.

Background Description

Research Status

• Detection Technology：UPLC-MS/MS technology, combined with a C18 column (1.7μm) and gradient elution with 0.1% formic acid - acetonitrile, achieves impurity separation within 8 minutes, with a detection limit as low as 0.003 ng/mL for high-precision trace impurity detection.

• Formation Mechanism：Formed by the acylation reaction of 4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)pyridazine-3-carboxylic acid with cyclopropanecarbonyl chloride under the action of an alkaline catalyst (such as triethylamine). Optimizing the dosage of the catalyst and the reaction pH can effectively inhibit side reactions.

• Safety Evaluation：In vitro cytotoxicity experiments show that the IC₅₀ of this impurity against HaCaT cells is 186.3 μM (Deucravacitinib IC₅₀ = 7.2 μM). Although the toxicity is lower than that of the main drug, its content in drugs still needs to be strictly controlled. Currently, long-term stability tests are being carried out to systematically study its degradation characteristics and potential risks under high temperature, high humidity, and light conditions.

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!