DI-591 NEW
| Price | $1420 | $1850 | $2970 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: DI-591 | CAS No.: 2245887-38-9 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | DI-591 |
| Description | DI-591 is an effective, high-affinity and cell-permeability inhibitor for DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 and nM and 10.4 nM, respectively, and has no obvious binding to DCN3, DCN4 and DCN5 proteins. |
| In vitro | DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively, and has no obvious binding to DCN3, DCN4 and DCN5 proteins. Therefore, DI-591 has a high binding affinity for recombinant human DCN1 and DCN2 proteins, and its selectivity is more than 1000 times that of recombinant human DCN3-5 protein [1]. DI-591 (0-10μM; 1 hour; KYSE70 cells) binds to the DCN1 and DCN2 proteins of the cells and disrupts the binding of the DCN1 and UBC12 proteins. DI-591 (10 μM; 24 hours; THLE2 cells) treatment can strongly increase the mRNA levels of NQO1 and HO1, resulting in the up-regulation of HO1 protein in the cells. It is worth noting that DI-591 has no effect on the mRNA level of NRF2. DI-591's selective inhibition of cullin 3's dienylation leads to the accumulation of NRF2 protein and its transcriptional activation. Knockdown experiments show that DCN1, but not DCN2, plays a key role in the regulation of dimerization of cullin 3 but not other cullins. DI-591 is an excellent probe compound for studying the role of cullin 3 CRL (Cullin-RING E3 ubiquitin ligase) in biological processes and human diseases. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | DI 591 | DI591 | DI-591 |
| Inhibitors Related | NSC697923 | Alrizomadlin | T521 | PYZD-4409 | NAcM-OPT | Nutlin-3 | PYR-41 | NSC232003 | NAE-IN-M22 | Indole-3-carbinol | Idasanutlin | SPOP-IN-6lc |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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