(E)-Guggulsterone NEW
| Price | $59 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: (E)-Guggulsterone | CAS No.: 39025-24-6 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | (E)-Guggulsterone |
| Description | Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.Guggulsterone, derived from resin of the guggul tree, is a competitive antagonist of FXR bothin vitroandin vivo.4Thecisstereoisomer of guggulsterone, (E)-guggulsterone, decreases chenodeoxycholic acid (CDCA)-induced FXR activation with an IC50value of 15 μM.5,6By inhibiting CDCA-induced transactivation of FXR, guggulsterone lowers low-density lipoprotein cholesterol and triglyceride levels in rodents fed a high cholesterol diet.4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF:PBS (pH 7.2) (1:4) : 0.2 mg/mL (0.64 mM), Sonication is recommended. DMSO : 0.25 mg/mL (0.8 mM), Sonication is recommended. DMF : 10 mg/mL (32.01 mM), Sonication is recommended. Ethanol : 1 mg/mL (3.2 mM), Sonication is recommended. |
| Keywords | Guggulsterone | (E)Guggulsterone | (E) Guggulsterone |
| Inhibitors Related | Melamine | Mycophenolate Mofetil | Clozapine N-Oxide | L-Threonic acid magnesium salt | SN-38 | Isonicotinic acid | Urolithin A | Ampyrone | Lansoprazole sulfide | Tulipalin A | 4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide | Nicotinamide N-oxide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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