EN460 NEW

EN460

Modify Date: 2024-01-02 15:53:56

EN460 structure	Common Name	EN460
	CAS Number	496807-64-8	Molecular Weight	460.79
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C22H12ClF3N2O4	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Purity		Quantity		Budget		Inquiry

Use of EN460 EN460 is a small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1); interacts selectively(IC50=1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.IC50 value: 1.9 uM [1]Target: ERO1 inhibitorin vitro: Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells.

• Properties

• Spectrum

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 Names

Name	en460

 EN460 Biological Activity

Description	EN460 is a small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1); interacts selectively(IC50=1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.IC50 value: 1.9 uM [1]Target: ERO1 inhibitorin vitro: Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Blais JD, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003.

 Chemical & Physical Properties

Molecular Formula	C22H12ClF3N2O4
Molecular Weight	460.79
PSA	56.40000
LogP	3.28560
Storage condition	2-8℃

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