Enpatoran hydrochloride NEW
| Price | $273 |
| Package | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-09 |
Product Details
| Product Name: Enpatoran hydrochloride | CAS No.: 2101945-93-9 |
| Purity: 99.88% | Supply Ability: 10g |
| Release date: 2025/05/09 |
Product Introduction
Bioactivity
| Name | Enpatoran hydrochloride |
| Description | Enpatoran hydrochloride (M5049 hydrochloride) is an orally active, selective, and potent TLR7/8 inhibitor with antiviral activity for the study of autoimmune diseases and COVID-19 pneumonia. |
| In vitro | 0.01 nM-10 μM Enpatoran hydrochloride, was able to inhibit IL-6 production induced by all ligands (e.g., miR-122, Let7c RNA, Alu RNA, and R848) with IC50 values ranging from 35 to 45 nM. [1] |
| In vivo | Injection of R848 (25 μg intraperitoneally) into mice was able to dose-dependently inhibit IL-6 and IFN-α production after pretreatment with 1 mg/kg Enpatoran hydrochloride by oral gavage. Enpatoran hydrochloride exhibited good bioavailability after oral administration of 1.0 mg/kg (100% in mice, 87% in rats, and 84% in dogs). Following intravenous administration, Enpatoran hydrochloride has a moderate half-life (1.4 hours in mice, 5.0 hours in rats, and 13 hours in dogs), which is associated with its high plasma clearance (1.4 L/h/kg in mice, 1.2 L/h/kg in rats, and 0.59 L/h/kg in dogs, respectively) and large volume of distribution (2.7 L/kg in mice, 8.7 L/kg in rats, and 8.7 L/kg in dogs, respectively). /in mice, 8.7 L/kg in rats, and 5.7 L/kg in dogs, respectively). [1] |
| Storage | keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 10.00 mg/mL (28.03 mM), Sonication is recommended. |
| Keywords | TLR8 | TLR7 | Antiviral |
| Inhibitors Related | BTA-188 | Hydroxychloroquine | Chloroquine phosphate | Oxytetracycline Hydrochloride | Chloranil | Chloroquine | CU-115 | Valganciclovir hydrochloride | Imiquimod | TLR3-IN-1 | Resiquimod | Stevioside |
| Related Compound Libraries | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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