ERα degrader-2 NEW
| Price | $263 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-14 |
Product Details
| Product Name: ERα degrader-2 | CAS No.: 2235396-63-9 |
| Purity: 99.71% | Supply Ability: 10g |
| Release date: 2025/05/14 |
Product Introduction
Bioactivity
| Name | ERα degrader-2 |
| Description | ERα degrader-2 is a selective and potent estrogen receptor (SERD) degrader with anticancer activity, exhibiting an EC50 value of 0.3 nM for ERα degradation. It can be used for the prevention and treatment of HER-positive breast cancer. |
| In vitro | In MCF-7 cells,ERα degrader-2 (0.01-40 nM) decreases ERα expression but does not fully degrade ERα even at a higher biochemical concentration. |
| In vivo | ERα degrader-2 (oral administration; 2-6 mg/kg; once daily; 21 days) demonstrates significant tumor growth inhibition in mice. Additionally, ERα degrader-2 (oral gavage; single dose of 2 mg/kg) exhibits superior pharmacokinetic properties compared to AZD9496, with a plasma exposure (AUC) of 16073.7 h*ng/mL, a half-life of 12.1 hours, and an oral availability of 80.5%[1]. |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 1.66 mg/mL (3.37 mM), Sonication is recommended. |
| Keywords | ERα degrader-2 | ERα degrader2 | ERα degrader 2 | ERK | ERalpha degrader-2 | ERa degrader-2 |
| Inhibitors Related | TBHQ | Notoginsenoside R1 | Lidocaine | Ro-3306 | Astragaloside IV | Olomoucine | Lidocaine hydrochloride | Tauroursodeoxycholate sodium | Honokiol | Tauroursodeoxycholate | ROCK-IN-5 | Nisin Z |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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