EST73502 hydrochloride NEW
| Price | $228 | $1400 | $1820 |
| Package | 2mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-27 |
Product Details
| Product Name: EST73502 hydrochloride | CAS No.: 2307458-82-6 |
| Supply Ability: 10g | Release date: 2025/07/27 |
Product Introduction
Bioactivity
| Name | EST73502 hydrochloride |
| Description | EST73502 hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with K i s of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 hydrochloride has antinociceptive activity with reduced opioid-induced relevant adverse events[1]. |
| In vivo | EST73502 hydrochloride administered orally (10-40 mg/kg) demonstrates a dose-dependent analgesic effect, achieving a peak reduction in pain of 64% with an Effective Concentration (EC 50) of 14 mg/kg in the paw pressure test on CD1 male mice [1]. Additionally, intraperitoneal injections of EST73502 hydrochloride (5 mg/kg; twice daily for 10 days) significantly mitigate mechanical allodynia caused by partial sciatic nerve ligation (PSNL) in these mice, showing a maximum efficacy of 56% [1]. This is observed in the same CD1 male mouse model using PSNL to simulate the condition [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | EST-73502 Hydrochloride | EST73502 Hydrochloride | EST73502 hydrochloride | EST 73502 Hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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