Product Details
| Product Name:
FRG8701 |
CAS No.:
108498-50-6 |
| Supply Ability:
10g |
Release date:
2025/08/22 |
Product Introduction
Bioactivity
| Name | FRG8701 |
| Description | FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM. |
| In vitro | The inhibitory potency of FRG8701 is almost the same as that of famotidine and approximately 33 times greater than that of cimetidine.Positive chronotropic response to histamine at 10-5 M is dose dependently inhibited by FRG8701 (FRG-8701) famotidine or cimetidine;?and the IC50 values of FRG8701, famotidine and cimetidine are 3.3, 3.0 and 108.6 (×10-7M), respectively. |
| In vivo | FRG8701 effectively inhibits the formation of gastric lesions induced by various necrotizing agents, demonstrating its protective effects on the gastrointestinal tract. Oral administration of FRG8701 produces a dose-dependent reduction in the development of gastric lesions caused by stress, indomethacin, and the formation of duodenal ulcers due to mepirizole, with ED50 values ranging from 1.1 to 9.4 mg/kg for gastric lesions and 1.7 to 6.9 mg/kg for each ulcer model. Additionally, in pylorus-ligated rats, intraduodenal delivery of FRG8701 dose-dependently decreases total acid output. Furthermore, FRG8701, whether administered orally or intraperitoneally at doses of 10 or 30 mg/kg, significantly prevents gastric mucosal lesions induced by 0.4 N HCl+50% ethanol, underscoring its potential as a protective agent against gastrointestinal damage. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | HistamineReceptor | Histamine Receptor | Histamine H2-receptor | FRG-8701 | FRG8701 | FRG 8701 |
| Inhibitors Related | Chlorphenesin | Meclizine dihydrochloride | Mirtazapine | Lidocaine | Famotidine | Mebhydrolin napadisylate | Sodium butanoate | Amitriptyline hydrochloride | Nizatidine | Alginic acid | Trazodone hydrochloride | Mianserin hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$2500.00/100mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-08-21 |
United States