Galegine hydrochloride NEW
| Price | Get Latest Price | ||
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Galegine hydrochloride | CAS No.: 2368870-39-5 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Galegine hydrochloride |
| Description | Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains[1][2]. |
| In vitro | Pre-treatment with Galegine hydrochloride (10 μM-3 mM; 5 h) enhances insulin-independent glucose absorption in 3T3-L1 adipocytes concentration-dependently, without impacting cell health. Similarly, incubation (1 μM-1 mM, 5 h) boosts glucose intake in L6 myotubes without affecting viability[1]. Galegine hydrochloride (0.3-300 μM; 24 hours) slightly decreases basal glycerol release and significantly reduces isoprenaline-induced glycerol release in 3T3-L1 adipocytes. In H4IIE rat hepatoma cells, Galegine hydrochloride (10 or 300 μM) up to 6 hours progressively activates AMPK, reaching peak activation at 360 min and maintaining twofold activation at 24 hours with 300 μM, showing a stronger effect at 300 μM than at 10 μM. A one-hour incubation triggers concentration-dependent AMPK activation in both 3T3L-1 adipocytes and L-6 myotubes, as well as in a human kidney cell line (HEK293)[1]. |
| In vivo | Galegine hydrochloride (63 mg/kg; feed; daily for 11 days) significantly reduces body weight[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5.2 mg/mL (31.78 mM), Sonication is recommended. H2O : 43.33 mg/mL (264.77 mM), Sonication is recommended. |
| Keywords | Galegine hydrochloride | Galegine Hydrochloride |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Ampicillin sodium | Acetic Acid | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Copper(Ⅱ) Sulfate | Doxycycline | Chitosan oligosaccharide | BES |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $2.00/100kg |
VIP1Y
|
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
|
2025-06-19 | |
| $0.00/1kg |
VIP4Y
|
Dingwang Technology (Wuhan) Co., Ltd.
|
2022-10-28 | |
| $0.00/1kg |
VIP1Y
|
Chongqing Soarwin Technology Co., Ltd
|
2025-04-09 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY